Title: New Labdane diterpenes from Hedychium yunnanense with cytotoxicity and inhibitory effects on nitric oxide production
First Author: Li, Yu-Peng; Zhao, Si-Meng; Xu, Jun-Ju; Zeng, Guang-Zhi; Li, Yan; Tan, Ning-Hua; Yang, Ye
Abstract: Two new labdane diterpenes, hedychenoids A (1) and B (2), were isolated from the rhizomes of Hedychium yunnanense, together with four known ones hedychenone (3), forrestin A (4), villosin (5) and calcaratarin C (6). Their structures were determined on the basis of NMR (1D and 2D) and mass spectroscopic analysis. Compounds 2, 3 and 5 exhibited cytotoxicity against SGC-7901 with IC50 values of 14.88 +/- 0.52, 7.08 +/- 0.21 and 7.76 +/- 0.21g/ml, 3 and 5 against HeLa with IC50 values of 9.76 +/- 0.48 and13.24 +/- 0.63g/ml, respectively. Compounds 2, 5 showed inhibitory effects against nitric oxide production in LPS and IFN--induced RAW 264.7 murine macrophages with IC50 values of 6.57 +/- 0.88 and 5.99 +/- 1.20g/ml, respectively.
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Page Number: 2669-2674
Issue: 23
Subject: Chemistry, Applied ; Chemistry, Medicinal
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PubYear: 2016
Volume: 30
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