Title: Isolation of lingzhifuran A and lingzhilactones D-F from Ganoderma lucidum as specific Smad3 phosphorylation inhibitors and total synthesis of lingzhifuran
First Author: Ding, Wei-Yi; Ai, Jun; Wang, Xin-Long; Qiu, Fayang G.; Lv, Qing; Fang, Ping; Hou, Fan-Fan; Yan, Yong-Ming; Cheng, Yong-Xian
Abstract: Lingzhifuran A (1) and lingzhilactones D-F (2-4), four new phenolic meroterpenoids were isolated from the fruiting bodies of Ganoderma lucidum. Their structures were identified by spectroscopic data. Chiral HPLC analysis indicates the racemic nature of 2-4. Chiral separation followed by X-ray diffraction analysis discloses the absolute configuration of (-)-2. Compounds 1 and 2 could selectively inhibit TGF-beta 1-induced Smad3 phosphorylation in rat renal tubular epithelial cells, representing novel scaffolds of selective Smad3 activation inhibitors. Total synthesis accompanied by in vivo rodent experiments reveals antifibrotic activities of 1 against kidney fibrosis. Finally, a plausible biosynthetic pathway for 1 was proposed.
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Page Number: 77887-77897
Issue: 81
Subject: Chemistry
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PubYear: 2016
Volume: 6
Publication Name: RSC ADVANCES
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