| Abstract: |
Twelve previously undescribed lanostane-type triterpenoids, including three triterpenoids with a γ-lactone ring,
namely applanlactones A？C, four highly oxygenated lanostane triterpenoids, namely methyl applaniate A and
applanoic acids B？D, as well as ？ve C21 nortriterpenoids, applanones A？E were isolated from the fruiting bodies
of Ganoderma applanatum (Pers.) Pat.. Their structures were elucidated by 1D, 2D NMR and MS spectra, as well
as X-ray crystallographic analyses. Meanwhile, applanlactone A, methyl applaniate A and applanoic acid B
showed inhibitory e？ects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth
factor-β1 (TGF-β1) in vitro. |