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论文 |
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论文题目: |
Flavan-3-ols Having a gamma-Lactam from the Roots of Actinidia arguta Inhibit the Formation of Advanced Glycation End Products in Vitro
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论文题目英文: |
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作者: |
Jang, Dae Sik; Lee, Ga Young; Lee, Yun Mi; Kim, Young Sook; Sun, Hang; Kim, Dong-Hee; Kim, Jin Sook
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论文出处: |
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年: |
2009
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卷: |
57 |
期: |
4 |
页: |
397-400 |
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发表期刊: |
CHEMICAL & PHARMACEUTICAL BULLETIN |
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影响因子: |
1.623
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摘要: |
Two new flavan-3-ols, 6-(2-pyrrolidinone-5-yl)-(-)-epicatechin (1) and 8-(2-pyrrolidinone-5-yl)-(-)-epicatechin (2), as well as five known compounds, (-)-epicatechin (3), (+)-catechin (4), proanthocyanidin B-4 (5), (+)-pinoresinol, and p-hydroxybenzoic acid, were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation, particularly by extensive 1D- and 2D-NMR studies. All the isolates were evaluated in vitro for inhibitory activity on the formation of advanced glycation end products (AGEs). Of these, compounds 1-5 exhibited significant inhibitory activity against AGEs formation with IC50 values ranging from 10.1 to 125.2 mu m. |
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