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论文 |
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论文题目: |
Anti-Coxsackie Virus B3 Norsesquiterpenoids from the Roots of Phyllanthus emblica
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论文题目英文: |
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作者: |
Liu, Qing; Wang, Ya-Feng; Chen, Rong-Jie; Zhang, Mei-Ying; Wang, Yi-Fei; Yang, Chong-Ren; Zhang, Ying-Jun
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论文出处: |
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年: |
2009
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卷: |
72 |
期: |
5 |
页: |
969-972 |
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发表期刊: |
JOURNAL OF NATURAL PRODUCTS |
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影响因子: |
2.843
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摘要: |
Three new norsesquiterpenoid glycosides, 4'-hydroxyphyllaemblicin B (1) and phyllaemblicins E (2) and F (3), were isolated from the roots of Phyllanthus emblica, together with three known compounds, phyllaemblic acid (4), phyllaemblicin B (5), and phyllaemblicin C (6). Of these, 3 is a new norsesquiterpenoid dimer. The structures of 1-3 were established by spectroscopic data information and by acidic hydrolysis. The isolated compounds, together with two other known analogues, phyllaemblic acid methyl ester (7) and phyllaemblicin A (8), were evaluated for their antiviral activity toward coxsackie virus B3 (CVB3) by an in vitro cytopathic effect inhibitory assay. Compounds 5-7 exhibited strong anti-CVB3 activity. |
英文摘要: |
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