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论文 |
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论文题目: |
Vibralactones D-F from Cultures of the Basidiomycete Boreostereum vibrans
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论文题目英文: |
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作者: |
Jiang, Meng-Yuan; Zhang, Ling; Dong, Ze-Jun; Yang, Zhu-Liang; Leng, Ying; Liu, Ji-Kai
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论文出处: |
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年: |
2010
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卷: |
58 |
期: |
1 |
页: |
113-116 |
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发表期刊: |
CHEMICAL & PHARMACEUTICAL BULLETIN |
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影响因子: |
1.623
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摘要: |
Three new metabolites, vibralactones D-F (1-3) were isolated from cultures of the basidiomycete Boreostereum vibrans. The relative configuration of I was established on the basis of X-ray diffraction analysis, while the absolute configurations of 1-3 were assigned using a modified Mosher's method. Compound I showed weak inhibitory activities against isozymes of 11 beta-hydroxysteroid dehydrogenases (HSD) with IC50 values of 85.7 mu M (human HSD1), 295.2 mu M (mouse HSD1), and 87.1 mu M (human HSD2). |
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