学术活动 |
|
友情链接 |
|
|
|
论文 |
|
论文题目: |
Chemical Constituents of Excoecaria acerifolia and Their Bioactivities
|
论文题目英文: |
|
作者: |
Zhao, Yan-Li; He, Qiu-Xia; Li, Yang; Wang, Si-Feng; Liu, Ke-Chun; Yang, Yong-Ping; Li, Xiao-Li
|
论文出处: |
|
年: |
2010
|
卷: |
15 |
期: |
4 |
页: |
2178-2186 |
联系作者: |
|
发表期刊: |
MOLECULES |
第一作者所在部门: |
|
收录类别: |
|
影响因子: |
1.252
|
摘要: |
A new kaurane diterpenoid, 3 alpha, 18-dihydroxy-3 beta,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells. |
英文摘要: |
|
外单位作者单位: |
|
ISSN: |
|
|
|