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论文 |
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| 论文题目: |
Recombination of diterpenoid structure units: Synthesis of antitumor amides bearing functionalized bicyclo[3.2.1]octane ring
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| 论文题目英文: |
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| 作者: |
Mao, Zewei; Li, Yan; Chen, Jingbo; Wang, Yuanyuan; Zhang, Hongbin
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| 论文出处: |
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| 年: |
2010
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| 卷: |
20 |
| 期: |
14 |
| 页: |
4116-4119 |
| 联系作者: |
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| 发表期刊: |
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS |
| 第一作者所在部门: |
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| 收录类别: |
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| 影响因子: |
2.531
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| 摘要: |
In this work, 23 new amides (14-36) bearing a representative diterpenoid structure unit, the functionalized bicyclo[3.2.1]octane ring, have been synthesized and its antitumor potential is studied. In vitro studies demonstrate that a number of amides with the bicyclo[3.2.1]oct-3-en-2-one subunit are active against HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 tumor cell lines. The hybrid derivative, compound 20, was found to be the most potent compound (IC50 = 1.05 mu M against HL-60) and more active than cisplatin (DDP), the positive control. Additionally, compound 20 exhibited broad spectrum in vitro anticancer activity with IC50 values of 1.1-4.3 mu M against the five tested cancer cell lines. (C) 2010 Elsevier Ltd. All rights reserved. |
| 英文摘要: |
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