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论文题目: |
Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata
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论文题目英文: |
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作者: |
Feng, Tao; Wang, Rui-Rui; Cai, Xiang-Hai; Zheng, Yong-Tang; Luo, Xiao-Dong
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论文出处: |
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年: |
2010
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卷: |
58 |
期: |
7 |
页: |
971-975 |
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发表期刊: |
CHEMICAL & PHARMACEUTICAL BULLETIN |
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影响因子: |
1.623
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摘要: |
A total of 36 compounds (1-36) were obtained from the stem bark of Poncirus trifoliata including three new prenylated flavonoids, (-)-5,4'-dihydroxy-7,8-[(3 '',4 ''-cis-dihydroxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (1), (-)-5,4'-dihydroxy-7,8-[(3 ''-hydroxy-4 ''-one)-2 '',2 ''-dimethylpyrano]-flavone (2), and (-)-5,4'-dihydroxy-7,8-[(cis-3 ''-hydroxy-4 ''-ethoxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (3). The new structures were elucidated by means of spectroscopic methods. Compounds 1-20 were evaluated for their anti-human immunodeficiency virus-1 (HIV-1) activity, in which 2 showed significant anti-HIV-1 activity with high therapeutic index (T1) of 143.65. |
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