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论文 |
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论文题目: |
Pregnane alkaloids from Pachysandra axillaris
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论文题目英文: |
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作者: |
Sun, Yun; Yan, Yu-Xin; Chen, Jian-Chao; Lu, Lu; Zhang, Xian-Min; Li, Yan; Qiu, Ming-Hua
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论文出处: |
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年: |
2010
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卷: |
75 |
期: |
12 |
页: |
818-824 |
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发表期刊: |
STEROIDS |
第一作者所在部门: |
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收录类别: |
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影响因子: |
2.588
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摘要: |
Nine new pregnane alkaloids, pachysamines J-R (1-9), together with seven known ones, were isolated from Pachysandra axillaris. The chemical structures of the new alkaloids were elucidated by spectroscopic methods. All the compounds were evaluated for their inhibitory activities against HL-60, SMMC-7721, A549, SK-BR-3, and PANC-1 cell lines. Compound 15 possessed moderate activities against A-549, SK-BR-3, and PANC-1 cells, with the IC50 values of 11.17, 4.17, and 10.76 mu M, respectively. Besides, compound 11 showed cytotoxicities against A-549 cell, with the IC50 values as 24.94 mu M. (C) 2010 Published by Elsevier Inc. |
英文摘要: |
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