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论文题目: |
A Piperidine Alkaloid and Limonoids from Arisaema decipiens, a Traditional Antitumor Herb Used by the Dong People
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论文题目英文: |
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作者: |
Zhao, Fu-Wei; Luo, Min; Wang, Yue-Hu; Li, Ma-Lin; Tang, Gui-Hua; Long, Chun-Lin
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论文出处: |
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年: |
2010
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卷: |
33 |
期: |
11 |
页: |
1735-1739 |
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发表期刊: |
ARCHIVES OF PHARMACAL RESEARCH |
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影响因子: |
1.074
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摘要: |
A new piperidine alkaloid and three known tetranortriterpenoids were isolated from the methanol extracts of the rhizomes of Arisaema decipiens Schott (Araceae) and their chemical structures were identified as ( ) (2R*,3S*,6S*) N,2 dimethyl 3 hydroxy 6 (9 phenylnonyl) piperidine (1), 6 deacetylnimbin (2), 28 deoxonimbolide (3) and nimbin (4) The N methylated derivative (la) of 1 was synthesized Compound 1 exhibited weak inhibitory activity against the MCF 7 cell line, while compound la showed potential inhibitory activity against the MCF 7 cell line with an IC50 value of 4 6 mu M and weak inhibitory activity against K562 and SK OV 3 cells This plant in genus Arisaema is firstly reported as the source of limonoids that are considered a natural antitumor herbal medicine |
英文摘要: |
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