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论文 |
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论文题目: |
Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla
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论文题目英文: |
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作者: |
Wang, Kou; Zhou, Xiao-Yu; Wang, Yuan-Yuan; Li, Ming-Ming; Li, Yin-Shan; Peng, Li-Yan; Cheng, Xiao; Li, Yan; Wang, Yi-Ping; Zhao, Qin-Shi
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论文出处: |
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年: |
2011
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卷: |
74 |
期: |
1 |
页: |
12-15 |
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发表期刊: |
JOURNAL OF NATURAL PRODUCTS |
第一作者所在部门: |
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收录类别: |
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影响因子: |
2.843
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摘要: |
An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC50 values of 13.96 and 23.28 mu M, respectively. Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC50 = 6.73 mu g/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KO-induced contraction. |
英文摘要: |
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