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论文 |
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论文题目: |
Pentagalloylglucose downregulates cofilin1 and inhibits HSV-1 infection
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论文题目英文: |
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作者: |
Pei, Ying; Xiang, Yang-Fei; Chen, Jia-Nan; Lu, Chun-Hua; Hao, Jing; Du, Qian; Lai, Chi-choi; Qu, Chang; Li, Shen; Ju, Huai-Qiang; Ren, Zhe; Liu, Qiu-Ying; Xiong, Sheng; Qian, Chui-Wen; Zeng, Fan-Li; Zhang, Pei-Zhuo; Yang, Chong-Ren; Zhang, Ying-Jun; Xu, J
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论文出处: |
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年: |
2011
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卷: |
89 |
期: |
1 |
页: |
98-108 |
联系作者: |
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发表期刊: |
ANTIVIRAL RESEARCH |
第一作者所在部门: |
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收录类别: |
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影响因子: |
3.613
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摘要: |
To investigate the anti-herpesvirus mechanism of pentagalloylglucose (PGG), we compared the proteomic changes between herpes simplex virus type 1 (HSV-1) infected MRC-5 cells with or without PGG-treatment, and between non-infected MRC-5 cells with or without PGG-treatment by 2-DE and MS-based analysis. Differentially expressed cellular proteins were mainly involved with actin cytoskeleton regulation. Significantly, PGG can down-regulate cofilin1, a key regulator of actin cytoskeleton dynamics. PGG can inhibit HSV-1-induced rearrangements of actin cytoskeleton which is important for infectivity. Furthermore, cofilin1 knockdown by siRNA also inhibited the HSV-1-induced actin-skeleton rearrangements. Both PGG-treatment and cofilin1 knockdown can reduce HSV-1 DNA, mRNA, protein synthesis and virus yields. Altogether, the results suggested that down-regulating cofilin1 plays a role in PGG inhibiting HSV-1 infection. PGG may be a promising anti-herpesvirus agent for drug development. (C) 2010 Elsevier B.V. All rights reserved. |
英文摘要: |
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