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论文 |
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论文题目: |
Spirocyclic Acylphloroglucinol Derivatives from Hypericum beanii
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论文题目英文: |
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作者: |
Chen, Xuan-Qin; Li, Yan; Li, Kun-Zhi; Peng, Li-Yan; He, Juan; Wang, Kou; Pan, Zheng-Hong; Cheng, Xiao; Li, Ming-Ming; Zhao, Qin-Shi; Xu, Gang
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论文出处: |
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年: |
2011
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卷: |
59 |
期: |
10 |
页: |
1250-1253 |
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发表期刊: |
CHEMICAL & PHARMACEUTICAL BULLETIN |
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收录类别: |
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影响因子: |
1.623
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摘要: |
Four new acylphloroglucinols with an unusual 6/6/5 spirocyclic skeleton, hyperbeanols A-D (1-4), were isolated from the methanol extract of Hypericum beanii along with 16 known compounds. Their structures were established on the basis of spectroscopic and X-ray diffraction analysis. Hyperbeanols A-C were three stereoisomers different only at the relative configuration of C-4 and C-13, which were distinguished by the nuclear Oyerhauser effect spectroscopy (NOESY) spectroscopic data in combination with the single X-ray analysis of hyperbeanol A (1). The cytotoxic activity of hyperbeanols A D against the cancer cell lines SK-BR-3, HL-60, SMMC-7721, PANC-1, MCF-7, and K562 was also evaluated. |
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