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论文 |
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论文题目: |
A cytotoxic 4 alpha-methyl steroid from the aerial parts of Cimicifuga foetida L
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论文题目英文: |
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作者: |
Nian, Yin; Wang, Hai-Yan; Su, Jia; Zhou, Lin; Qiu, Ming-Hua
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论文出处: |
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年: |
2012
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卷: |
83 |
期: |
2 |
页: |
293-297 |
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FITOTERAPIA |
第一作者所在部门: |
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影响因子: |
1.2
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摘要: |
A new 4 alpha-methyl sterol, cimisterol A (1), together with five known compounds (2-6), were isolated from the aerial parts of Cimicifuga foetida L The new compound's structure was determined with the help of extensive 1D and 2D NMR spectroscopy. Compound 1 exhibited broad-spectrum and potent cytotoxic activities against human HL-60, Jurkat, K562, U937, HepG-2, and SGC-7091 cell lines, with IC50 values of 7.23, 2.89, 6.88, 3.38, 4.21, and 4.89 mu M, respectively. Compound 3 showed moderate to weak activities to all cell lines, except for SGC-7091, having 1050 values ranging from 13.37 to 17.72 mu M. This is the first time a cytotoxic 4 alpha-methyl sterol constituent was discovered from Cimicifuga spp. (C) 2011 Elsevier B.V. All rights reserved, |
英文摘要: |
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