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论文 |
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论文题目: |
Isoprenylated Flavonoid and Adipogenesis-Promoting Constituents of Dodonaea viscosa
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论文题目英文: |
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作者: |
Zhang, Lai-Bin; Ji, Jun; Lei, Chun; Wang, He-Yao; Zhao, Qin-Shi; Hou, Ai-Jun
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论文出处: |
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年: |
2012
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卷: |
75 |
期: |
4 |
页: |
1405 |
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发表期刊: |
JOURNAL OF NATURAL PRODUCTS |
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影响因子: |
2.843
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摘要: |
Ten new isoprenylated flavonol derivatives, dodoviscins A-J (1-10), and seven known compounds (11-17) were isolated from the aerial parts of Dodonaea viscosa. Compounds 1, 2, 4, 5, 7-9, 5,7,4'-trihydroxy-3',5'-bis(3-methyl-2-buten-1-yl)-3-methoxyflavone (11), 5,7,4'-trihydroxy-3',5'-bis(3-methyl-2-buten-1-yl)-3,6-dimethoxyflavone (12), 5,7,4'-trihydroxy-3'-(4-hydroxy-3-methylbutyl)-5'-(3-methyl-2-buten-1-yl)-3,6-dinnethyoxyflavone (13), sakuranetin (14), and blumeatin (15) promoted adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells. Compounds 1, 13, and 15 also enhanced the accumulation of lipid droplets and induced upregulation of the expression of the adipocyte-specific genes aP2 and GLUT4. |
英文摘要: |
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