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论文 |
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论文题目: |
Seven New Secoiridoids with Anti-Hepatitis B Virus Activity from Swertia angustifolia
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论文题目英文: |
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作者: |
He, Kang; Ma, Yun-Bao; Cao, Tuan-Wu; Wang, Hong-Ling; Jiang, Fu-Qiang; Geng, Chang-An; Zhang, Xue-Mei; Chen, Ji-Jun
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论文出处: |
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年: |
2012
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卷: |
78 |
期: |
8 |
页: |
1634 |
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发表期刊: |
PLANTA MEDICA |
第一作者所在部门: |
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收录类别: |
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影响因子: |
1.96
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摘要: |
Seven new secoiridoids, swertianglide (1) and swertianosides A-F (2-7), together with fifteen known compounds, were isolated from the whole plants of Swertia angustifolia. Their structures were elucidated on the basis of extensive spectroscopic analyses ([alpha](D), UV, IR, MS, 1D- and 2D-NMR). Fourteen compounds were evaluated for their anti-hepatitis B virus (HBV) activities on the Hep G 2.2.15 cell line in vitro. Compound 2, an unusual secoiridoid glycoside dimer, showed significant activities inhibiting the secretion of HBsAg (IC50 0.18 mM, SI 3.11) and HBeAg (IC50 0.12 mM, SI 4.67). |
英文摘要: |
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