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论文 |
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论文题目: |
Clusters of Sudden Unexplained Death Associated with the Mushroom, Trogia venenata, in Rural Yunnan Province, China
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论文题目英文: |
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作者: |
Shi, Guo-Qing; Huang, Wen-Li; Zhang, Jian; Zhao, Hong; Shen, Tao; Fontaine, Robert E.; Yang, Lin; Zhao, Su; Lu, Bu-Lai; Wang, Yue-Bing; Ma, Lin; Li, Zhao-Xiang; Gao, Yang; Yang, Zhu-Liang; Zeng, Guang
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论文出处: |
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年: |
2012
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卷: |
7 |
期: |
5 |
页: |
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发表期刊: |
PLOS ONE |
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影响因子: |
4.351
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摘要: |
Introduction: Since the late 1970's, time-space clusters of sudden unexplained death (SUD) in northwest Yunnan, China have alarmed the public and health authorities. From 2006-2009, we initiated enhanced surveillance for SUD to identify a cause, and we warned villagers to avoid eating unfamiliar mushrooms. Methods: We established surveillance for SUD, defined as follows: sudden onset of serious, unexplained physical impairment followed by death in,24 hours. A mild case was onset of any illness in a member of the family or close socially related group of a SUD victim within 1 week of a SUD. We interviewed witnesses of SUD and mild case-persons to identify exposures to potentially toxic substances. We tested blood from mild cases, villagers, and for standard biochemical, enzyme, and electrolyte markers of disease. Results: We identified 33 SUD, a 73% decline from 2002-2005, distributed among 21 villages of 11 counties. We found a previously undescribed mushroom, Trogia venenata, was eaten by 5 of 7 families with SUD clusters compared to 0 of 31 other control-families from the same villages. In T. venenata-exposed persons SUD was characterized by sudden loss of consciousness during normal activities. This mushroom grew nearby 75% of 61 villages that had time-space SUD clusters from 1975 to 2009 compared to 17% of 18 villages with only single SUD (p < 0.001, Fisher's exact test). Discussion: Epidemiologic data has implicated T. venenata as a probable cause of clusters of SUD in northwestern Yunnan Province. Warnings to villagers about eating this mushroom should continue. |
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