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论文 |
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论文题目: |
New Minor Spirostane Glycosides from Ypsilandra thibetica
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论文题目英文: |
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作者: |
Zhang, Xu-Dong; Chen, Chang-Xiang; Yang, Jun-Yun; Ni, Wei; Liu, Hai-Yang
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论文出处: |
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年: |
2012
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卷: |
95 |
期: |
7 |
页: |
2180 |
联系作者: |
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发表期刊: |
HELVETICA CHIMICA ACTA |
第一作者所在部门: |
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影响因子: |
1.396
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摘要: |
A further phytochemical investigation on the whole plants of Ypsilandra thibetica yielded three new spirostane glycosides, named ypsilandrosides MO (13). Their structures were established as (3 beta,11a,25R)-3,11-dihydroxyspirost-5-en-12-one 3-{O-a-L-rhanmopyranosyl-(1?4)-O-L-rhanmopyranosyl-(1?4)-O-[a-L-rhanmopyranosyl-(1?2)]-beta-D-glucopyranoside} (1), (3 beta,7 beta,25R)-spirost-5-ene-3,7-diol 3-{O-a-L-rhanmopyranosyl-(1?4)-O-a-L-rhanmopyranosyl-(1?4)-O-[a-L-rhanmopyranosyl-(1?2)]-beta-D-glucopyranoside} (2), and (3 beta,7a,25R)-spirost-5-ene-3,7,17-triol 3-{O-a-L-rhanmopyranosyl-(1?4)-O-a-L-rhanmopyranosyl-(1?4)-O-[a-L-rhanmopyranosyl-(1?2)]-beta-D-glucopyranoside} (3) by means of a combination of MS, 1D- and 2D-NMR spectroscopic methods, and chemical degradation. Among them, compound 3 is the first pennogenin (=(3 beta,25R)-spirost-5-ene-3,17-diol) saponin whose aglycone contains an OH group at C(7). Compounds 13 were evaluated for the inhibition of the growth of five tumor cell lines, but all of them proved to be inactive. |
英文摘要: |
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