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论文 |
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论文题目: |
Chemical Constituents of Saniculiphyllum guangxiense
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论文题目英文: |
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作者: |
Geng, Chang-An; Huang, Xiao-Yan; Lei, Li-Gong; Zhang, Xue-Mei; Chen, Ji-Jun
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论文出处: |
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年: |
2012
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卷: |
9 |
期: |
8 |
页: |
1508-1516 |
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发表期刊: |
CHEMISTRY & BIODIVERSITY |
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影响因子: |
1.659
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摘要: |
The first phytochemical investigation on Saniculiphyllum guangxiense resulted in the isolation of two new triterpenoids, 16 beta-hydroxybryodulcosigenin (3) and 3a-O-feruloylolean-12-en-27-oic acid (6), together with six known compounds, menisdaurin (1), purshianin (2), oleanolic acid (4), 3 beta-hydroxyolean-12-en-27-oic acid (5), beta-sitosterol (7), and daucosterol (8), which were characterized by extensive spectroscopic analyses and in one case by X-ray diffraction. According to this primary investigation, S. guangxiense is rich in nitrile glucosides and triterpenoids, of which menisdaurin (1; 0.06%) and purshianin (2; 0.015%) are the main constituents. Compounds 16 were assayed for their anti-hepatitis B virus (HBV) activities against the secretion of HBsAg and HBeAg, as well as HBV DNA replication on Hep G 2.2.15 cell line in vitro. The most active compound, menisdaurin (1), inhibits HBV DNA replication with an IC50 value of 0.32 mM (SI>11.97). |
英文摘要: |
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