学术活动 |
|
友情链接 |
|
|
|
论文 |
|
论文题目: |
Novel Dibenzo[b,e]oxepinones from the Freshwater-Derived Fungus Chaetomium sp YMF 1.02105
|
论文题目英文: |
|
作者: |
Shen, Kai-Ze; Gao, Suo; Gao, Yan-Xiu; Wang, An-Ran; Xu, Yao-Bo; Sun, Rong; Hu, Pei-Gen; Yang, Guo-Fu; Li, Ai-Ji; Zhong, Dan; Liu, Hai-Yang; Dong, Jin-Yan
|
论文出处: |
|
年: |
2012
|
卷: |
78 |
期: |
17 |
页: |
1837-1843 |
联系作者: |
|
发表期刊: |
PLANTA MEDICA |
第一作者所在部门: |
|
收录类别: |
|
影响因子: |
|
摘要: |
Six new dibenzo[b,e]oxepinone metabolites, chaetones A-F (1-6), as well as three known compounds, 1-hydroxy-6-methyl-8-hydroxymethyl-xanthone (7), citreorosein (8), and emodin (9), were obtained from a freshwater-derived fungal strain Chaetomium sp. YMF 1.02105. Their structures were established on the basis of extensive spectroscopic data analysis and comparison with spectroscopic data reported. Compounds 1-6 are further additions to the small group of dibenzo[ b,e]oxepinones represented by arugosins A-H. Compounds 1-7 were tested for their cytotoxic activities against A549, Raji, HepG2, MCF-7, and HL-60 cell lines. The results showed that compound 3 had significant cytotoxicitywith IC50 values of 1.2, 1.8, 1.9, 2.3, and 1.6 mu g/mL, respectively, against the five cancer cell lines. All compounds showed modest antimicrobial activity against Staphylococcus aureus (ATCC 6538) in standard disk assays. |
英文摘要: |
|
外单位作者单位: |
|
ISSN: |
|
|
|