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论文 |
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论文题目: |
New Triterpenoids from the Fruits of Schisandra wilsoniana and Their Biological Activities
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论文题目英文: |
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作者: |
Gao, Xue-Mei; Li, Yun-Qi; Shu, Li-Dan; Shen, Yan-Qiong; Yang, Li-Ying; Yang, Liu-Meng; Zheng Yong-Tang; Sun, Han-Dong; Xiao, Wei-Lie; Hu, Qiu-Fen
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论文出处: |
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年: |
2013
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卷: |
34 |
期: |
3 |
页: |
827-830 |
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发表期刊: |
BULLETIN OF THE KOREAN CHEMICAL SOCIETY |
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影响因子: |
1.257
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摘要: |
Investigation of an organic extract of the fruits Schisandra wilsoniana led to the isolation of two new highly oxygenated. nortriterpenoids, named schilancidilactones V-W (1-2). Their structures were elucidated by spectroscopic evidence. Compounds 1-2 feature a double bond between C-7 and C-8 compared with related known nortriterpenoids isolated from the genus Schisandra. Compounds 1 and 2 were tested for their anti-HIV-1 activities and cytotoxicity. The results revealed that compounds 1 and 2 showed moderate anti-HIV-1 activities with EC50 3.05 and 2.87 mu g/mL, respectively, and compound 1 showed high cytotoxicity against KB and MDA-MB-231 cell with IC50 values of 3.18 and 5.22 mu M, respectively. |
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