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论文 |
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论文题目: |
Acylated iridoid glycosides and acylated rhamnopyranoses from Gmelina arborea flowers
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论文题目英文: |
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作者: |
Gu, Wei; Hao, Xiao-Jiang; Liu, Hong-Xin; Wang, Yue-Hu; Long, Chun-Lin
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论文出处: |
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年: |
2013
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卷: |
6 |
期: |
4 |
页: |
681-685 |
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发表期刊: |
PHYTOCHEMISTRY LETTERS |
第一作者所在部门: |
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影响因子: |
1.364
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摘要: |
Nine acylated iridoid glycosides (1-9), five acylated rhamnopyranoses (10-14) and verbascoside (15) were isolated from Gmelina arborea flowers, including 5 new compounds (1, 2, and 10-12). The cytoprotective activity of 11 selected compounds (1-8, 10, 11, and 15) against CCl4-induced cytotoxicity on liver was determined. Compounds 1, 2, 4, 7, 8 and 15 displayed hepatoprotective activity. 6-O-alpha-L-(2 '',3 ''-di-O-trans-p-hydroxycinnamoyl)rhamnopyranosylcatalpol (2) exhibited the most potent cytoprotective effect with an EC50 value of 42.5 mu M (SI = 19.3) compared with biphenyldimethylesterate (DDB, EC50 = 277.3 mu M, SI = 9.8) and bicylo-ethanol (EC50 = 279.2 mu M, SI = 12.2). Among the acylated iridoid glycosides, the compounds (2 and 8) containing phenolic hydroxy groups were more active than were those lacking them. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. |
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