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论文 |
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论文题目: |
Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia
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论文题目英文: |
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作者: |
Fu, Yan-hui; Di, Ying-tong; He, Hong-ping; Li, Shun-lin; Zhang, Yu; Hao, Xiao-jiang
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论文出处: |
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年: |
2014
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卷: |
77 |
期: |
1 |
页: |
57-62 |
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发表期刊: |
JOURNAL OF NATURAL PRODUCTS |
第一作者所在部门: |
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收录类别: |
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影响因子: |
2.843
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摘要: |
Two new bisindole alkaloids, angustifonines A (1) and B (2), comprising the union of a rearranged monoterpenoid quinoline and an aspidospermine alkaloid, as well as 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia angustifolia. Their structures and absolute configurations were elucidated by a combination of MS, NMR, and computational methods. Angustifonines A and B exhibited cytotoxicity against various human cancer cell lines with IC50 values of 2.71-16.22 mu M. A possible biosynthesis pathway toward the new bisindole alkaloids 1 and 2 is presented. |
英文摘要: |
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