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论文题目: |
Collective Total Synthesis of Tetracyclic Diquinane Lycopodium Alkaloids (+)-Paniculatine, (-)-Magellanine, (+)-Magellaninone and Analogues Thereof
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论文题目英文: |
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作者: |
Jiang, Shi-Zhi; Lei, Ting; Wei, Kun; Yang, Yu-Rong
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论文出处: |
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年: |
2014
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卷: |
16 |
期: |
21 |
页: |
5612-5615 |
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影响因子: |
5.128
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摘要: |
The collective total synthesis of tetracyclic diquinane Lycopodium alkaloids, (+)-paniculatine, (-)-magellanine, (+)-magellaninone, and two analogues (-)-13-epi-paniculatine and (+)-3-hydroxyl-13-dehydro-paniculatine, has been accomplished. By logic-guided addition of a strategically useful hydroxyl group at C-3 of paniculatine, the formidable tetracyclic core was rapidly synthesized utilizing a site-specific and stereoselective aldol cyclization, thus making the ABD -> ABCD tetracyclic approach to diquinane Lycopodium alkaloids attainable for the first time. |
英文摘要: |
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