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论文 |
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论文题目: |
Isolation and Complete Structural Assignment of Lycopodium Alkaloid Cernupalhine A: Theoretical Prediction and Total Synthesis Validation
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论文题目英文: |
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作者: |
Dong, Liao-Bin; Wu, Ya-Nan; Jiang, Shi-Zhi; Wu, Xing-De; He, Juan; Yang, Yu-Rong; Zhao, Qin-Shi
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论文出处: |
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年: |
2014
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卷: |
16 |
期: |
10 |
页: |
2700-2703 |
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影响因子: |
5.128
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摘要: |
Cernupalhine A (1) is a trace Lycopodium alkaloid (0.7 mg) possessing a new C17N skeleton with an unusual hydroxydihydrofuranone motif newly isolated from Palhinhaea cernua L. Its complete structural assignment, including absolute stereochemistry, was established through a combination of high-field NMR techniques and computational methods and further unequivocal confirmation by the first asymmetric total synthesis. Following the first total synthesis of lobscurinine (3), 1 was achieved via regio- and stereoselective cyanide ion addition and subsequent acid treatment. |
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