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论文题目: |
Design, synthesis and antitumor activity of novel 8-substituted 2,3,5,6-tetrahydrobenzo[1,2-b:4, 5-b'] difuran imidazolium salt derivatives
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论文题目英文: |
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作者: |
Sun, Cheng-Jun; Chen, Wen; Li, Yan; Liu, Lan-Xiang; Wang, Xue-Quan; Li, Li-Juan; Zhang, Hong-Bin; Yang, Xiao-Dong
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论文出处: |
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年: |
2014
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卷: |
4 |
期: |
31 |
页: |
16312-16319 |
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发表期刊: |
RSC ADVANCES |
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摘要: |
A series of novel 8-substituted 2,3,5,6-tetrahydrobenzo[ 1,2-b:4,5-b'] difuran imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of the 5,6-dimethyl-benzimidazole ring and substitution of the imidazolyl-3-position with a 2-naphthylmethyl or 4-methylbenzyl group were vital for modulating cytotoxic activity. Compound 43 was found to be the most potent derivative and exhibited cytotoxic activities selectively against breast carcinoma (MCF-7), colon carcinoma (SW480), myeloid leukaemia (HL-60) and lung carcinoma (A549) with an IC50 value 65.0-fold, 48.5-fold, 21.2-fold and 19.9-fold more sensitive to DDP, respectively. |
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