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论文 |
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论文题目: |
Chemical constituents from Euphorbia wallichii and their biological activities
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论文题目英文: |
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作者: |
Yang, DS; Peng, WB; Yang, YP; Liu, KC; Li, XL; Xiao, WL
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论文出处: |
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年: |
2015
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卷: |
17 |
期: |
9 |
页: |
17-9 |
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发表期刊: |
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH |
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摘要: |
One rare diterpenoid which was an unusual phorbol derivative possessing a 5-ene-7-oxo functional group, wallichiioid A (1), and 17 known compounds (2-18) were isolated from the aerial parts of Euphorbia wallichii. The structures and relative configuration of these compounds were elucidated on the basis of extensive spectroscopic interpretation. All the known compounds were isolated from E. wallichii for the first time. Diterpenoids 1-5 were tested for their cytotoxicity against five cancer cell lines (A-549, MCF-7, Hep G2, HeLa, and P388) and showed IC50 values in the range of 8.19-29.72g/mL. The antiangiogenic activities of diterpenoids 1-5 were also evaluated using a zebrafish model. |
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