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论文 |
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论文题目: |
Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2+2] Cycloaddition and C-H Functionalization
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论文题目英文: |
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作者: |
Zhou, M; Li, XR; Tang, JW; Liu, Y; Li, XN; Wu, B; Qin, HB; Du, X; Li, LM; Wang, WG; Pu, JX; Sun, HD
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论文出处: |
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年: |
2015
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卷: |
17 |
期: |
24 |
页: |
17-24 |
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摘要: |
Scopariusicides A (1) and B (2), two novel immunosuppressive unsymmetrical cyclobutane derivatives, were isolated from the aerial parts of Isodon scoparius. Moreover, based on the results of phytochemical investigation, a concise stereocontrolled synthesis of scopariusicide A and its analogues with enhanced biological activities was efficiently achieved using the main diterpenoid (3) isolated from this plant as a readily available starting material. A crossed intermolecular [2 + 2] photocycloaddition and a Pd-catalyzed sp3 C-H bond beta-arylation were used synergistically to access the highly congested unsymmetrical cyclobutane core with four contiguous stereocenters. |
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