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论文 |
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论文题目: |
Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N-9-Methyl Group in the Conformation and Bioactivity
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论文题目英文: |
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作者: |
Wang, Z; Zhao, SM; Zhao, LM; Chen, XQ; Zeng, GZ; Tan, NH
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论文出处: |
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年: |
2015
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卷: |
10 |
期: |
12 |
页: |
10-12 |
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发表期刊: |
PLOS ONE |
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摘要: |
One new cyclic hexapeptide named rubipodanin A (1), which is the first identified natural N-desmonomethyl Rubiaceae-type cyclopeptide, together with six known Rubiaceae-type cyclopeptides (2-7) were obtained using the TLC cyclopeptide protosite detection method with ninhydrin from the roots and rhizomes of Rubia podantha. The cyclopeptide structures were elucidated by extensive spectroscopic analysis, including 1D-NMR, 2D-NMR, IR, UV and MS. The solution conformation and biological activities of 1 and RA-V (4) were evaluated, and the results demonstrated that the N-9-methyl group plays a vital role in the maintenance of the conformation and bioactivity. |
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