中国科学院昆明植物研究所
当前位置:首页 > 机构概况 > 人才队伍
left
人才队伍
专家人才
 

姓  名:
普诺·白玛丹增
学  科:
药物化学
人才类别:
青年创新促进会优秀会员
电话/传真:
0871-65223616  
电子邮件:
punopematenzin@mail.kib.ac.cn
通讯地址:
云南省昆明市蓝黑路132号 650201
更多信息:
  
简历:

1. 1997.9-2001.7,云南大学生化学院,应用化学专业,获学士学位; 

2. 2001.9-2004.7,云南大学药学院,有机化学专业,获硕士学位; 

3. 2004.9-2007.6,中科院昆明植物研究所,植物化学专业,获博士学位; 

4. 2007.7-2009.1,中科院昆明植物研究所,助理研究员; 

5. 2009.1-2012.12,中科院昆明植物研究所,副研究员; 

6. 2011.1月,硕士研究生导师。 

7. 2013.1月,晋升为研究员。 

8. 2015.1月,博士研究生导师。

研究领域:

主要从事天然产物化学和药物化学研究。重点开展以下两个方面的研究: 

1. 重要药用类群植物(五味子科和香茶菜属,即一科一属)及其内生菌新颖次生代谢产物与生物功能的基础和应用基础研究 

2. 横断山脉区域藏药药用植物的药效物质基础及其应用研究。

社会任职:
获奖及荣誉:

1.2014年云南省自然科学奖特等奖(排名第五),项目名称:五味子化学研究 

2.2013年云南省自然科学奖一等奖(排名第二),项目名称:香茶菜属植物二萜及其抗癌活性研究 

3.2013年入选国家自然科学基金优秀青年科学基金项目; 

4.2013年入选中科院西部之光人才项目; 

5.2012年入选云南省青年联合会第十届委员会委员; 

6.2011年入选中国科学院首届青年创新促进会; 

7.2011入选云南省第十四批中青年学术和技术带头人后备人才计划; 

8. 2010年获中科院卢嘉锡青年人才奖
代表论著:

迄今为止,在Nat. Prod. Rep.Cancer Res.Org. Lett., Chem. Comm.Cell Death & Dis.等国内外刊物上发表论文220余篇(SCI 200余篇),以第一、通讯及共同通讯作者发表论文107篇(学科前15%论文40篇,IF>5论文18篇,IF>9论文2篇)。申请发明专利21项(16项已授权)。

部分代表论文如下:

1. Yi-Ming Shi, Kun Hu, Gennaro Pescitelli*, Miao Liu, Xiao-Nian Li, Xue Du, Wei-Lie Xiao, Han-Dong Sun, and Pema-Tenzin Puno*, Schinortriterpenoids with Identical Configuration but Distinct ECD Spectra Generated by Non-Degenerate Exciton Coupling, Org. Lett., 2018, 20, 1500-1504. (IF:6.579)

2. Miao Liu, Wei-Guang Wang, Han-Dong Sun, and Jian-Xin Pu*, Diterpenoids from Isodon species: An update, Nat. Prod. Rep., 2017, 34, 1090-1140. (IF:11.014)  

3. Xiao-Yan Sun, Wei-Guang Wang, Jiao ChenXue-Ting Cai, Jie Yang, Yang Yang, Huai-Jiang Yan, Xiao-Lan Chen, Juan Ye, Wu-Guang Lu, Chun-Ping Hu, Han-Dong Sun, Jian-Xin Pu*, and Peng Cao*, The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects, Cancer Res., 2017, 77(4), 926-936. (IF: 9.122)

4. Xu-Nian Zhou, Grace Gar-Lee Yue, Andrew Man-Lok Chan, Stephen Kwok-Wing Tsui, Kwok-Pui Fung, Han-Dong Sun, Jian-Xin Pu*, Clara Bik-San Lau*, Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway inbreast cancer, Biochem. Pharmacol., 2017, 142, 58-70. (IF:4.581)5. Yun Che, Jing-Nan Wang, Zu-Yang Yuan, Yuan Li, Zhi-Liang Lu, Zhi-Rong Zhang, Jin-Yao Zhang, Jun Wan, Han-Dong Sun, Zhao-Li Chen*, Jian-Xin Pu*, Jie He*, The therapeutic effects of Longikaurin A, a natural ent-kauranoid, in esophageal squamous cell carcinoma depend on ROS accumulation and JNK/p38 MAPK activation, Toxicol. Lett., 2017, 280, 106-115. (IF:3.858)

6. Bing-Chao Yan, Wei-Guang Wang, Dong-Bao Hu, Xiang Sun, Ling-Mei Kong, Xiao-Nian Li, Xue Du, Shi-Hong Luo, Yan Liu, Yan Li, Han-Dong Sun, and Jian-Xin Pu*, Phomopchalasins A and B, Two Cytochalasans with Polycyclic-Fused Skeletons from the Endophytic Fungus Phomopsis sp. shj2, Org. Lett., 2016, 18, 1108-1111. (IF:6.579)

Yi-Ming Shi, Song-Liang Cai, Xiao-Nian Li, Miao Liu, Shan-Zhai Shang, Xue Du, Wei-Lie Xiao, Jian-Xin Pu*, and Han-Dong Sun*, LC-UV Guided Isolation and Structure Determination of Lancolide E: a Nortriterpenoid with a Tetracyclo[5.4.0.02,4.03,7]undecane-Bridged System from a “Talented” Schisandra Plant, Org. Lett., 2016, 18(1), 100-103. (IF:6.579)

8. *, Jian-Xin Pu*, and  Org. Lett., 2016, 18(9), 2284-2287. (IF:6.579)

9.  Xu-Nian Zhou, Grace Gar-Lee Yue, Ming-Hua Liu, Zhi-Li Zuo, Julia Kin-Ming Lee, Ming-Yue Li, Stephen Kwok-Wing Tsui, Kwok-Pui Fung, Han-Dong Sun, Jian-Xin Pu*, and Clara Bik-San Lau*, Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling, Oncotarget, 2016, 7(50), 82820-82835. (IF: 5.008)

10. Min Zhou, Xing-Ren Li, Jian-Wei Tang, Yang Liu, Xiao-Nian Li, Bin Wu, Hong-Bo Qin, Xue Du, Li-Mei Li, Wei-Guang Wang, Jian-Xin Pu*, and Han-Dong Sun, Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular [2 + 2] Cycloaddition and C-H Functionalization, Org. Lett., 2015, 17(24), 6062-6065. (IF:6.579)

11. Zheng-Xi Hu, Yi-Ming Shi, Wei-Guang Wang, Xiao-Nian Li, Xue Du, Miao Liu, Yan Li, Yong-Bo Xue, Yong-Hui Zhang*, Jian-Xin Pu*, and Han-Dong Sun, Kadcoccinones AF, New Biogenetically Related Lanostane-Type Triterpenoids with Diverse Skeletons from Kadsura coccinea, Org. Lett., 2015, 17(18), 4616-4619. (IF:6.579)

12. Y-J Liao, Hai-Yan Bai, Z-H Li, J Zou, J-W Chen, F Zheng, J-X Zhang, S-J Mai, Mu-Sheng Zeng, Han-Dong Sun, Jian-Xin Pu*, and Dan Xie*, Longikaurin A, a natural ent-kaurane, induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells, Cell Death and Disease, 2014, 5, e1137. (IF: 5.014)

13. Min Zhou, Hui-Chun Geng, Hai-Bo Zhang, Ke Dong, Wei-Guang Wang, Xue Du, Xiao-Nian Li, Fei He, Hong-Bo Qin, Yan Li, Jian-Xin Pu*, and Han-Dong Sun*, Scopariusins, a new class of ent-halimane diterpenoids isolated from Isodon scoparius, and biomimetic synthesis of scopariusin A and isoscoparin N, Org. Lett., 2013, 15(2), 314-317. (IF: 6.324)

14. Min Zhou, Hai-Bo Zhang, Wei-Guang Wang, Ning-Bo Gong, Rui Zhan, Xiao-Nian Li, Xue Du, Li-Mei Li, Yan Li, Yang Lu, Jian-Xin Pu*, and Han-Dong Sun*, Scopariusic Acid, a New Meroditerpenoid with a Unique Cyclobutane Ring Isolated from Isodon scoparius, Org. Lett., 2013, 15(17), 4446-4449. (IF: 6.324)

15. Wei Zhao, Wei-Guang Wang, Xiao-Nian Li, Xue Du, Rui Zhan, Juan Zou, Yan Li, Hai-Bo Zhang, Fei He, Jian-Xin Pu*, and Han-Dong Sun*, Neoadenoloside A, a highly functionalized diterpene C-glycoside, from Isodon adenolomus, Chem. Commun., 2012, 48(62), 7723-7725. (IF: 6.378)

16. Juan Zou, Xue Du, Guo Pang, Yi-Ming Shi, Wei-Guang Wang, Rui Zhan, Ling-Mei Kong, Xiao-Nian Li, Yan Li, Jian-Xin Pu*, and Han-Dong Sun*, Ternifolide A, a New Diterpenoid Possessing a Rare Macrolide Motif from Isodon ternifolius, Org. Lett., 2012, 14(12), 3210-3213. (IF: 6.142) 总引次数:14

17. Wei-Guang Wang, Xue Du, Xiao-Nian Li, Hai-Yan Wu, Xu Liu, Shan-Zhai Shang, Rui Zhan, Cheng-Qin Liang, Ling-Mei Kong, Yan Li, Jian-Xin Pu*, and Han-Dong Sun*, New Bicyclo[3.1.0]hexane Unit ent-Kaurane Diterpene and Its seco-Derivative from Isodon eriocalyx var. laxiflora, Org. Lett., 2012, 14(1), 302-305. (IF: 6.142)

18. Yong-Bo Xue, Jian-Hong Yang, Xiao-Nian Li, Xue Du, Jian-Xin Pu*, Wei-Lie Xiao, Jia Su, Wei Zhao, Yan Li, and Han-Dong Sun*, Henrischinins A-C: Three New Triterpenoids from Schisandra henryi, Org. Lett., 2011, 13(6), 1564-1567. (IF: 5.862) 总引次数:11

19. Fei He, Jian-Xin Pu*, Sheng-Xiong Huang, Yuan-Yuan Wang, Wei-Lie Xiao, Li-Mei Li, Jing-Ping Liu, Hai-Bo Zhang, Yan Li, and Han-Dong Sun*, Schinalactone A, a New Cytotoxic Triterpenoid from Schisandra sphenanthera, Org. Lett., 2010, 12(6), 1208-1211. (IF: 5.250)

20. Jian-Xin Pu, Wei-Lie Xiao, Yang Lu, Rong-Tao Li, Hong-Mei Li, Li Zhang, Sheng-Xiong Huang, Xian Li, Qin-Shi Zhao, Qi-Tai Zheng, and Han-Dong Sun*, Kadlongilactones A and B, Two Novel Triterpene Dilactones from Kadsura longipedunculata Possessing a Unique Skeleton, Org. Lett., 2005, 7(22), 5079-5082. (IF: 4.368)

承担科研项目情况:

    获国家自然科学基金(5项,包括1项优青和1NSFC-云南联合基金重点项目)、中科院、云南省科技厅以及中科院昆明植物所自主基金等项目15项。部分项目信息如下:

1国家自然科学基金优秀青年科学基金项目天然产物化学100万元项目负责人。起止时间:2014.01-2016.12,课题编号:21322204 

2NSFC-云南联合基金项目云南三江并流区域香茶菜属植物二萜及其抗癌活性研究210万元项目负责人。起止时间:2014.01-2017.12,课题编号:U1302223 

3国家自然科学基金面上项目具有免疫抑制活性的天然对映-贝壳杉烷二萜类化合物的研究50万元项目负责人。起止时间:2012.01-2015.12,课题编号:81172939 

4国家自然科学基金面上项目状香茶菜中具有免疫抑制活性新颖杂二萜的发现、合成及作用机制研究84万元项目负责人。起止时间:2017.01-2020.12,课题编号:81673329 

5. 国家自然科学基金青年项目西南地区南五味子属植物中新颖结构类型化合物及生物活性成分的研究19万元项目负责人。起止时间:2010.01-2012.12,课题编号:20902093 

6中国科学院西部之光人才培养计划香茶菜属植物中对映-贝壳杉烷二萜成分及其抗肿瘤成药性评价30万元,项目负责人(2013.01-2015.12)。 

7中国科学院知识创新工程重要方向项目-横断山区香茶菜属植物生物活性成分及其应用基础研究,60万元,项目负责人(2011.01-2013.12)。

中国科学院昆明植物研究所

版权所有 Copyright © 2002-2016 中科院昆明植物研究所,All Rights Reserved 【滇ICP备05000394号
地址:中国云南省昆明市蓝黑路132号  邮政编码:650201    点击这里联系我们  手机版