中国科学院昆明植物研究所
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专家人才
 

姓  名:
纪 旭
学  科:
药理学
人才类别:
研究员
电话/传真:
0871-65216611  
电子邮件:
jixu@mail.kib.ac.cn
通讯地址:
云南省昆明市蓝黑路132号 650201
更多信息:
  
简历:

教育经历 

19988 -20027  中国药科大学药物分析系,学士学位 

20029-20033  日本京都大学人类环境学研究科药理学研究室,研究生 

20034-20053  日本京都大学人类环境学研究科药理学研究室,硕士 

20054-20083  日本京都大学人类环境学研究科药理学研究室, 博士 

工作经历 

20084- 20132月 日本国立循环器病研究中心病态基因医学部,研究员 

20133- 20142月 中国科学院昆明植物研究所 副研究员,青年科学家小组长 

20143- 至今 中国科学院昆明植物研究所 研究员,青年科学家小组长,天然药物活性筛选中心主任

在日活动经历 

曾任日本京都大学中国人留学生联谊会副会长 

曾任日本京都地区中国人留学生联谊会副会长 

现任留日中国人生命科学协会理事,副会长 

大阪市日中友好协会 成员 

作为留学生代表参加了在神户召开的第九届世界华商大会 

作为留学生代表受到了国家领导人胡锦涛主席,温家宝总理,贾庆林政协主席的接见 

日本药理学会会员 

日本循环器病学会会员 

日本心血管内分泌代谢学会会员 

2008年度西日本地区优秀留学人员 

2009年西日本地区中国留学人员庆祝建国60周年征文评选动 二等奖 

2009留日中国人生命科学协会第11届学术交流会 优秀奖 

2011留日中国人生命科学协会第13届学术交流会 学术委员会主席

研究领域:
社会任职:
获奖及荣誉:
代表论著:

发表论文

1. Ji X, Naito Y, Weng H, Ma X, Endo K, Kito N, Yanagawa N, Yu Y, Li J, Iwai N. Renoprotective mechanisms of pirfenidone in hypertension-induced renal injury: through anti-fibrotic and anti-oxidative stress pathways. Biomed Res. 2013;34:309-319.(通讯作者) 

2. Ji X, Trandafir CC, Wang A, Kurahashi K. Effects of the experimental subarachnoid hemorrhage on the eicosanoid receptors in nicotine-induced contraction of the rat basilar artery. J Stroke Cerebrovasc Dis. 2013;22:1258-1262.(通讯作) 

3. Ji X, Wang A, Trandafir CC, Kurahashi K. Influence of experimental subarachnoid hemorrhage on nicotine-induced contraction of the rat basilar artery in relation to arachidonic acid metabolites signaling pathway. J Stroke Cerebrovasc Dis.2013;22:951-958.(通讯作者) 

4. Ji X, Wang A, Trandafir CC, Kurahashi K. Influence of experimental subarachnoid hemorrhage on nicotine-induced contraction of the rat basilar artery in relation to nicotinic acetylcholine receptors, calcium and potassium channels. J Stroke Cerebrovasc Dis.2013;22:371-377.(通讯作者) 

5. Weng H, Ji X, Naito Y, Endo K, Ma X, Takahashi R, Shen C, Hirokawa G, Fukushima Y, Iwai N. Pex11α deficiency impairs peroxisome elongation and division and contributes to nonalcoholic fatty liver in mice. Am J Physiol Endocrinol Metab.2013;304:E187-196. 

6. Endo K, Naito Y, Ji X, Nakanishi M, Noguchi T, Goto Y, Nonogi H, Ma X, Weng H, Hirokawa G, Asada T, Kakinoki S, Yamaoka T, Fukushima Y, Iwai N. MicroRNA 210 as a Biomarker for Congestive Heart Failure. Biol Pharm Bull. 2013,36:48-54. 

7. Ji X, Naito Y, Weng H, Endo K, Ma X, Iwai N. P2X7 deficiency attenuates hypertension and renal injury in deoxycorticosterone acetate (DOCA)-salt hypertension. Am J Physiol Renal Physiol.2012;303:F1207-1215. 

8.  Ji X, Naito Y, Hirokawa G, Weng H, Hiura Y, Takahashi R, Iwai N. P2X7 receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats.Hypertens Res. 2012;35:173-179. 

9. Weng H, Shen C, Hirokawa G, Ji X, Takahashi R, Shimada K, Kishimoto C, Iwai N. Plasma miR-124 as a biomarker for cerebral infarction. Biomed Res. 2011;32:135-141. 

10. Ji X, Takahashi R, Hiura Y, Hirokawa G,Fukushima Y, Iwai N. Plasma miR-208 as a biomarker of myocardial injury. Clin Chem. 2009;55:1944-1949. 

11. Ji X, Nishihashi T, Trandafir CC, Wang A, Shimizu Y, Kurahashi K.Pharmacological nature of nicotine-induced contraction in the rat basilar artery: Involvement of arachidonic acid metabolites. Eur J Pharmacol. 2007;577:109-114. 

12. Nishihashi T, Trandafir CC, Wang A, Ji X, Shimizu Y, Kurahashi K. Hypersensitivity to hydroxyl radicals in rat basilar artery after subarachnoid hemorrhage. J Pharmacol Sci. 2006;100:234-236. 

13. Trandafir CC, Nishihashi T, Ji X, Wang A, Kurahashi K. Cysteinyl leukotrienes and leukotriene B4 mediate vasoconstriction to arginine vasopressin in rat basilar artery. Clin Exp Pharmacol Physiol. 2005;32:1027-1033. 

14. Nishihashi T, Trandafir CC, Wang A, Ji X, Kurahashi K. Enhanced reactivity to vasopressin in rat basilar arteries during vasospasm after subarachnoid hemorrhage. Eur J Pharmacol. 2005;513:93-100. 

15. Wang A, Nishihashi T, Trandafir CC, Murakami S, Ji X, Shimizu Y, Kurahashi K. Involvement of endothelial COX metabolites in Noradrenaline-induced contraction in rat coronary artery. Clin Exp Pharmacol Physiol. 2005;32:628-632. 

16. Trandafir CC, Nishihashi T, Wang A, Murakami S, Ji X, Kurahashi K. Participation of vasopressin in the development of cerebral vasospasm in a rat model of subarachnoid haemorrhage. Clin Exp Pharmacol Physiol. 2004;31:261-266. 

17. Wang A, Nishihashi T, Trandafir CC, Murakami S, Ji X, Shimizu Y, Kurahashi K. Noradrenaline-induced contraction mediated by endothelial COX-1 metabolites in the rat coronary artery. J Cardiovasc Pharmacol. 2003;42:39-42. 

18. Kurahashi K, Nishihashi T, Trandafir CC, Wang A, Murakami S, Ji X. Diversity of endothelium-derived vasocontracting factors-arachidonic acid metabolites. Acta Pharmacol Sin. 2003;24:1065-1069. 

学会论文:

1. Ji X, Naito Y, Weng H, Endo K, Ma X, Iwai N.:The role of P2X7 receptor in hypertension and renal injury. The 16th Annual Scientific Meeting of The Cardiovascular Endocrinology and Metabolism. November, 2012. 

2. Ma X, Ji X, Sheng J, Hayashi T.: Palmatine stimulates 5'-AMP-activated protein kinase in isolated rat skeletal muscle. The 19th Symposium of Natural Medicines Development and Application. November, 2012. 

3. Ji X, Naito Y, Weng H, Ma X, Endo K, Iwai N.: Pirfenidone prevents the progression of renal injury in Dahl salt-sensitive rat. The 85th Annual Meeting of The Japanese Pharmacological Society. March, 2012. 

4. Naito Y, Tachibana S, Ando E, Furuya M, Nagata T, Ji X, Ma X, Endo K, Iwai N. Effects of antilipemic agent on SHRSP fed diet containing canola oil The 85th Annual Meeting of The Japanese Pharmacological Society. March, 2012. 

5. Weng H, Naito Y, Ji X, MA X, Iwai N.: Characterization of a PEX11a-deficient mouse. The 34th Annual Meeting of the Molecular Biology Society of Japan. December, 2011. 

6. Ji X, Iwai N.: Deletion of P2rx7 Attenuates Hypertension and Renal Injury in DOCA-salt Hypertension. The 75th Annual Scientific Meeting of the Japanese Circulation Society. August, 2011. 

7. Weng H, Ji X, Hirokawa G, Iwai N.: Brain Specific miRNAs as Biomarkers for Stroke. The 75th Annual Scientific Meeting of the Japanese Circulation Society. March, 2011 

8. Ji X, Weng H, Hiura Y, Iwai N.: Protective effects of Brilliant Blue G (BBG) on salt-induced hypertension and renal injury. The 33nd Annual Scientific Meeting of the Japanese Society of Hypertension. October, 2010. 

9. Ji X, Hirokawa G, Takahashi R, Hiura Y, Fukushima Y, Iwai N.: Plasma miR-208 as a Biomarker for Myocardial Infarction in Rats. The 74th Annual Scientific Meeting of the Japanese Circulation Society. March, 2010. 

10. Ji X, Hirokawa G, Takahashi R, Hiura Y, Fukushima Y, Iwai N.: Plasma Levels of miR-208 as a Biomarker of Myocardial Injury. The 82nd Annual Meeting of the Japanese Biochemical Society. October, 2009. 

11. Takahashi R, Weng H, Ji X, Hirokawa G, Iwai N.: Urinary micro-RNA as a significance indicator of renal failure. The 32nd Annual Scientific Meeting of the Japanese Society of Hypertension. October, 2009. 

12. Ji X, Takahashi R, Hirokawa G, Hiura Y, Iwai N.: Serum MicroRNAs are promising Biomarkers for several cardiovascular diseases. The 73rd Annual scientific Meeting of the Japanese Circulation Society. March, 2009. 

13. Ji X, Nishihashi T, Kurahashi K.: Influences of experimental SAH on arachidonic acid metabolisms, nAChRs, K (ATP) channel and L-type Ca2+ channel activities nicotine-induced contraction of the rat basilar artery. The 81th Annual Meeting of The Japanese Pharmacological Society. March, 2008. 

14. Ji X, Nishihashi T, Trandafir CC, Kurahashi K.: Influence of experimental subarachnoid hemorrhage (SAH) on nicotine-induced contraction in the rat basilar artery. 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists; 41st Annual scientific Meeting of the Australasian society of Clinical and Experimental Pharmacologists and Toxicologists, Adelaide, Australia. December, 2007. 

15. Ji X, Nishihashi T, Wang A, Kurahashi K.: Effects of LTB4, cysLT and and TXA2 antagonists on nicotine-induced endothelium-dependent contraction (EDC) in rat basilar artery. The 80th Annual Meeting of The Japanese Pharmacological Society. March, 2007. 

16. Kurahashi K, Wang A, Nishihashi T, Trandafir CC, Murakami S, Ji X.: Arginine vasopressin –induced contraction in rat basilar artery: Involvement of endothelium and COX metabolites. The Australian Health and Medical Research Congress.2006. 

17. Ji X, Nishihashi T, Trandafir CC, Wang A, Kurahashi K.: Nicotine-induced contraction in rat basilar artery: involvement of endothelialarachidonic acid metabolites. The 15th World Congress of Pharmacology, Bejing, China. July, 2006. 

18. Kurahashi K, Wang A, Nishihashi T, Trandafir CC, Ji X. Involvement  of endothelial COX metabolites in AVP-induced contraction in the rat basilar artery. The 15th World Congress of Pharmacology, Bejing, China. July, 2006. 

19. Ji X, Nishihashi T, Trandafir CC, Wang A, Kurahashi K.: Influence of experimental SAH on effects of levcromakalin, nifedipine and nicotinic acetylcholine receptor blockers in nicotine-induced contraction (EDC) in rat basilar artery. The 79th Annual Meeting of The Japanese Pharmacological Society. March, 2006. 

20. Trandafir CC, Nishihashi T, Ji X, Wang A, Kurahashi K.: Participation of Arginine Vasopressin and Leukotrienes in Development of Cerebral Vasospasm after Subarachnoid Hemorrhage. The 79th Annual Meeting of The Japanese Pharmacological Society. March, 2006. 

21. Kurahashi K, Nishihashi T, Trandafir CC, Wang A, Murakami S, Ji X, Lee W.: Arginine vasopressin –induced endothelium-dependent contraction of rat basilar artery in experimental sabarachiniod hemorrhage. International Symposium on The Genomic Hypertension Research and Therapy.2006. 

22. Ji X, Nishihashi T, Trandafir CC, Wang A, Kurahashi K.: Influence of experimental SAH on effects of PLA2 and PLC inhibitors in nicotine-induced endothelium-dependent contraction (EDC) in rat basilar artery. The 78th Annual Meeting of The Japanese Pharmacological Society. March, 2005. 

23. Trandafir CC, Nishihashi T, Ji X, Wang A, Kurahashi K.: Involvement of cysLT and LTB4 in vasopressin-induced contraction of rat basilar artery. The 78th Annual Meeting of The Japanese Pharmacological Society. March, 2005. 

24. Nishihashi T, Wang A, Murakami S, Trandafir CC, Ji X, Kurahashi K.: Investigation of blood components that cause acute or chronic vasospasm in rat model of experimental SAH. The 78th Annual Meeting of The Japanese Pharmacological Society. March, 2005. 

25. Nishihashi T, Trandafir CC, Wang A, Ji X, Kurahashi K.: Enhanced reactivity of vasopressin in rat basilar arteries after subarachnoid hemorrhage. The 78th Annual Meeting of The Japanese Pharmacological Society. March, 2005. 

26. Kurahashi K, Nishihashi T, Trandafir CC, Wang A, Ji X.: Changes in K-channel and electrogenic sodium pump activities of rat basilar artery after SAH-induction. The 78th Annual Meeting of The Japanese Pharmacological Society. March, 2005.  

27. Ji X, Nishihashi T, Trandafir CC, Wang A, Murakami S, Kurahashi K.: Influence of experimental SAH on effects of COX-1, COX-2 and 5-LOX inhibitors in nicotine-induced endothelium-dependent contraction (EDC) in rat basilar artery. The 77th Annual Meeting of The Japanese Pharmacological Society. March, 2004. 

28. Trandafir CC, Nishihashi T, Wang A, Murakami S, Ji X, Kurahashi K.: Cerebral vasospasm attenuated by SR 49059 in a rat model of SAH. The 77th Annual Meeting of The Japanese Pharmacological Society. March, 2004. 

29. Murakami S, Nishihashi T, Trandafir CC, Wang A, Ji X, Kurahashi K.: Role of endogeneous factors on induction of late vasospasm after SAH in rat basilar artery. The 77th Annual Meeting of The Japanese Pharmacological Society. March, 2004. 

30. Murakami S, Nishihashi T, Trandafir CC, Wang A, Ji X, Kurahashi K. Reseaarch on endogenous factors on induction of vasospasm after SAH in rat basilar artery-signaling process(PLC and PLA2),NOS and K+ channel system.: The 6th Sino-Japan Joint Hypertension Symposium & 2004 Shanghai Symposium on Hypertension.2004. 

31. Wang A, Nishihashi T, Trandafir CC, Murakami S, Ji X, Kurahashi K.: Influence of experimental SAH on effects of cyclooxyganase (COX)-inhibitors and lipid and lipid peroxidation inhibitor in arginine vasopressin (AVP)-induced contraction in the rat basilar artery. The 6th Sino-Japan Joint Hypertension Symposium & 2004 Shanghai Symposium on Hypertension.2004.

32. Nishihashi T, Trandafir CC, Wang A, Murakami S, Ji X, Kurahashi K.: Involvement of various factors in cerebrovaso-spasm after experimental SAH in rat. The National Coference on Adverse Drug Reactions and Clinical Safety Drug Administration & First China Shanghai International Congress of Pharmacoepidemiology and Drug Rational Use.2004. 

书籍:

倉橋和義、紀旭、王愛民。喫煙と循環:ニコチンによる内皮細胞依存性動脈収縮の多様性。«喫煙科学研究の歩み-1996年から2005年-»、日本喫煙科学研究財団2007年出版。

承担科研项目情况:

1. Japan Science and Technology Agency (JST)  

Adaptable and seamless technology transfer program through target-driven R&D  

(A-STEP-FS 2011-2012) 

负责(Principal Investigator): Ji Xu 

AS232Z02131G : Application enlargement of pirfenidone, an existing drug, for renal hypertension and heart failure. (1,700,000 JPY) 

2. 国家自然科学基金青年科学基金项目(23万;项目负责人;2014-2016 

项目批准号:81300609 

项目名称:嘌呤受体P2X4在盐敏感性高血压和肾损害中的作用研究。 

3. 国家自然科学基金面上项目(第一项目参与人;2014-2016 

项目批准号:81373292 

项目名称:抑制因子XFGAG构序列及其血栓形成与止血功能的影
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