中国科学院昆明植物研究所
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专家人才
 

姓  名:
李飞
学  科:
药物化学
人才类别:
研究员
电话/传真:
0871-65216953  
电子邮件:
lifeib@mail.kib.ac.cn
通讯地址:
云南省昆明市盘龙区蓝黑路132号,中国科学院昆明植物研究所 650201
更多信息:
  
简历:

1998/9 - 2002/7     江西中医药大学药学院,学士  

2002/9 - 2005/7     江西中医药大学药学院,硕士 

2005/9 - 2008/7     北京大学药学院,博士  

2008/8 - 2013/8     美国国立卫生研究院癌症研究所(NIH/NCI),博士后 

2013/10 - 2014/10   美国马里兰大学药学院,研究助理 

2014/10 - 2016/3    美国食品药品监督管理局(FDA),研究员 

2016/3 - 至今      中国科学院昆明植物研究所,研究员 

研究领域:

研究组以药理活性显著、疗效确切的天然产物为研究对象,应用代谢组学方法围绕肝病、癌症和肥胖等代谢性疾病的预防与治疗开展研究,整合化学生物学、分子生物学和各种组学实验手段,以期发现临床安全、疗效可靠的创新天然药物。 

1. 活性天然产物的成药性(ADMET)研究; 

2. 疗效确切的天然产物的作用靶标发现及其药效机理研究; 

3. 肝病、癌症和肥胖等代谢性疾病及其治疗药物的代谢组学研究。 

社会任职:
获奖及荣誉:

1.入选中组部青年千人计划 

2.入选中国科学院昆明植物研究所“引进海外杰出人才” 

3.入选云南省引进海外高层次人才计划 

4.获得美国NIH的优秀研究奖(FARE Award 

代表论著:

1.Fei Li, Xiuwei Yang, Kristopher W. Krausz, Robert G. Nichols, Wei Xu, Andrew D. Patterson, Frank J. Gonzalez*. Modulation of colon cancer by nutmeg. J Proteome Res, 2015, 14, 1937-1946. 

2.Yuanyuan Zhang, Fei Li, Yao Wang, Aaron Pitre, Zhongze Fang, Matthew W. Frank, Christopher Calabrese, Kristopher W. Krausz, Geoffrey Neale, Sharon Frase, Peter Vogel, Charles O. Rock,       Frank J. Gonzalez, John D. Schuetz*. Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun, 2015, 6, 8186. 

3.Changtao Jiang, Chen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jinwei Cai, Yunpeng Qi, Kristopher W. Krausz Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez*. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. J Clin Invest, 2015, 125, 386-402. 

4.Fei Li, Changtao Jiang, Michele C. Larsen, Justin Bushkofsky, Kristopher W. Krausz, Ting Wang, Colin R. Jefcoate, Frank J. Gonzalez*. Lipidomics reveals a link between CYP1B1 and SCD1 in promoting obesity. J Proteome Res, 2014, 13, 2679-2687. 

5.Fei Li, Changtao Jiang, Kristopher W. Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M.Fabre, James B. Mitchell, Andrew D. Patterson, Frank J. Gonzalez*. Microbiome remodeling leads to inhibition of intestinal farnesoid X receptor signaling and decreased obesity. Nat Commun, 2013, 4, 2384. 

6.Fei Li, Andrew D. Patterson, Kristopher W. Krausz, Changtao Jiang, Huichang Bi, Anastasia L. Sowers, John A. Cook, James B. Mitchell, Frank J. Gonzalez*. Metabolomics reveals that tumor xenografts induce liver dysfunction. Mol Cell Proteomics, 2013, 12, 2126-2135. 

7.Fei Li, Xiaoyan Pang, Kristopher W. Krausz, Changtao Jiang, Chi Chen, John A. Cook, Murali C. Krishna, James B. Mitchell, Frank J. Gonzalez, Andrew D. Patterson*. Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology. J Proteome Res, 2013, 12, 1369-1376. \

8.Fei Li, Andrew D. Patterson, Kristopher W. Krausz, Bernhard Dick, Felix J. Frey, Frank J. Gonzalez, Jeffrey R. Idle*. Metabolomics reveals the metabolic map of procainamide in humans and mice. Biochem Pharmacol, 2012, 83, 1435-1444. 

9.Yuanyuan Zhang, Fei Li, Andrew D. Patterson, Yao Wang, Kristopher W. Krausz, Geoffrey Neale; Sarah Thomas, Deepa Nachagari, Peter Vogel, Mary Vore, Frank J. Gonzalez, John D. Schuetz*. Abcb11 deficiency induces cholestasis coupled to impaired β-Fatty acid oxidation in mice. J Biol Chem, 2012, 287, 24784-24794. 

10.Fei Li, Andrew D. Patterson, Constance C. Höfer, Kristopher W. Krausz, Frank J. Gonzalez, Jeffrey R. Idle*. A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics. Biochem Pharmacol, 2011, 81, 1043-1053. 

    

承担科研项目情况:

1.中组部千人计划青年项目 

2.中国科学院“引进海外杰出人才”启动项目 

3.U.S.-China ProgramThe effect of Myristica fragrans on colon cancer and its mechanism of actionNIH R01 

 

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