1982-1986：西安医科大学药学专业毕业，理学学士。

1986-1989：中国科学院昆明植物研究所植物化学专业，理学硕士。

1992-1995：中国科学院昆明植物研究所植物化学专业，理学博士。

1996-1998：日本京都大学化学研究所博士后。

1989-1992：中国科学院昆明植物研究所实习研究员。

1992-1998：中国科学院昆明植物研究所助理研究员。

1998-2002：中国科学院昆明植物研究所副研究员。

2002.4-至今：中国科学院昆明植物研究所研究员、博士生导师。

获得国家杰出青年科学基金，主持NSFC-云南省联合基金重点项目、NSFC面上项目、国家科技重大专项“重大新药创制”专题、科技部863专项、中国科学院-香港求搓基金、云南省新药专项、企业等20余项，获得2000多万元经费资助。从30余种中药和药用植物中分离鉴定化合物600余个，获得新化合物100多个，报道5类新奇骨架的环烯醚萜内酯化合物并具有抗HBV活性；发现泽泻醇类化合物具有抗HBV活性，系统地开展了其结构修饰与作用机制研究；揭示2-氢喹啉酮及其衍生物具有抗HBV活性。发现新型抗抑郁活性化合物已完成其作为1类新药的临床前研究，正在进行新药研究与开发。发现新类型双吲哚生物碱、β-硝基烯、烯酰胺类、四氢异喹啉类等化合物对HIV-1具有抑制作用。培养博士、硕士毕业生10人，在读博士生7人，在读硕士3人。在Org Lett, J Nat Prod, Bioorg Med. Chem Lett, Planta Med, Tetrahadron, Tetrahedon Lett,《中国中药杂志》等杂志发表论文130余篇，其中SCI期刊收录论文70多篇；出版《抗艾滋病毒活性化合物》专著一部；申请专利24项和2项PCT国际专利，10项已授权。Org Lett, Bioorg Med Chem, Bioorg Med Chem Lett, Nat Prod Res,J Asian Nat Prod. Res等杂志审稿人，《中国中药杂志》编委。中国科学院“西部之光”人才培养和联合学者入选者、云南省防治艾滋病先进工作者和云南省防治非典先进工作者等荣誉称号。

药物化学：中药药效物质——抗乙型肝炎病毒（HBV）与抗精神疾病（抑郁、焦虑、癫痫、戒毒等）活性化合物的发现、结构修饰、优化与新药研究与开发。

利用天然药物化学各种现代分离和结构鉴定技术，以本研究组建立的抗乙型病毒性肝炎（HBV）体外、体内活性筛选和分子生物学作用机制研究技术平台，有机结构修饰和新药研发技术平台，以及合作伙伴中国科学院昆明动物研究所徐林研究员组完整的抗精神疾病（抑郁、焦虑、癫痫、戒毒等）现代药理学研究条件，主要开展抗乙型肝炎病毒（HBV）与抗精神疾病（抑郁、焦虑、癫痫、戒毒等）活性化合物的发现、结构修饰、优化与新药研究与开发，为发现和提供新的临床药物奠定科学基础。

1. 陈纪军等，《抗艾滋病病毒活性化合物》,云南科技出版社，2002

2. 陈纪军，《三萜及其苷》（见王锋鹏教授主编的《现代天然产物化学》。北京，科学出版社，2009）

 

近5年代表性研究论文

1.  Chang-An Geng, Xue-Mei Zhang, Yun-Bao Ma, Zhi-Yong Jiang, Jie Luo, Jun Zhou, Hong-Ling Wang, Ji-Jun Chen*. Swerilactones E–G, three unusual lactones from Swertia mileensis.Tetrahedron Lett 2010, 51: 2483–2485

2. Chang-An Geng; Xue-Mei Zhang; Yun-Bao Ma; Zhi-Yong Jiang; Ji-Feng Liu; Jun Zhou; Ji-Jun Chen*.Three new secoiridoid glycoside dimers from Swertia mileensis J Asian Nat Prod Res 2010, 12 ( 6): 542–548

3.  Ji-Feng Liu, Zhi-Yong Jiang, Chang-An Geng, Xiao-Bin Zou, Yao Shi, Yun-Bao Ma, Xue-Mei Zhang, Ji-Jun Chen*.Two new phenylpropanoid derivatives and other constituents from Illicium simonsii active against oral microbial organisms. Planta Med 2010,76:1464-1467

4.  Ji-Feng Liu, Zhi-Yong Jiang, Quan Zhang, Yao Shi, Yun-Bao Ma1, Ming-Jin Xie, Xue-Mei Zhang, Ji-Jun Chen*. Henrylactones A–E and anti-HBV constituents from Illicium henryi. Planta Med 2010,76:152-158

5.  Ai-Xue Zuo, Yong Shena, Zhi-Yong Jiang, Xue-Mei Zhang, Jun Zhou, Jun L, Ji-Jun Chen*.Three new dimeric orcinol glucosides from Curculigo orchioides. Helv Chim Acta 2010, 93: 504-510

6.  Ai-Xue Zuo, Yong Shen, Xue-Mei Zhang, Zhi-Yong Jiang, Jun Zhou, Jun Lu¨, Ji-Jun Chen*. Four new trace phenolic glycosides from Curculigo orchioides. J Asian Nat Prod Res 2010, 12, 43–50

7.  Ai-Xue Zuo, Yong Shen, Zhi-Yong Jiang, Xue-Mei Zhang, Jun Zhou, Jun Lü, Ji-Jun Chen*.Three new phenolic glycosides from Curculigo orchioides G. Fitoterapia 2010, 81(7):910-913.

8.  Yong Shen, Ai-Xue Zuo, Zhi-Yong Jiang, Xue-Mei Zhanga, Hong-Ling Wang, Ji-Jun Chen*. Five New C19-Diterpenoid Alkaloids from Aconitum hemsleyanum. Helv Chim Acta 2010, 93: 482-489

9.  Yong Shen, Ai-Xue Zuo, Zhi-Yong Jiang, Xue-Mei Zhang, Hong-Ling Wang, Ji-Jun Chen*.Four New Nor-Diterpenoid Alkaloids from Aconitum brachypodum. Helv Chim Acta, 2010,93: 863-868

10. Chang-An Geng, Xue-Mei Zhang, Yun-Bao Ma, Yong Shen, Ai-Xue Zuo, Ji-Feng Liu, Jun Zhou, Jie Luo, Zhi-yong Jiang,Ji-Jun Chen*. Swerilactones C and D, anti-HBV new lactones from a traditional Chinese herb: Swertia mileensis .Org. Lett. 2009, 11 (21), 4838–4841

11. Chang-An Geng, Zhi-Yong Jiang, Yun-Bao Ma, Jie Luo; Xue-Mei Zhang, Hong-Ling Wang, Yong Shen, Ai-Xue Zuo, Jun Zhou, Ji-Jun Chen*. Swerilactones A and B, anti-HBV new lactones from a traditional Chinese herb: Swertia mileensis as a treatment for viral hepatitis.Org Lett, 2009, 11(18):4120-4123

12. Xin-Liang Chang，Zhi-Yong Jiang, Yun-Bao Ma, Xue-Mei Zhang，Karl W. K. Tsim，Ji-Jun Chen*. Two new compounds from the roots of Ligusticum chuanxiong. J Asian Nat Prod Res, 2009, 11 (9): 805-810

13. Quan Zhang, Zhi-Yong Jiang, Jie Luo, Yun-Bao Ma， Ji-Feng Liu, Rui-Hua Guo, Xue-Mei Zhang, Jun Zhou, Wei Niu, Fei-Fei Du, Li Li, Chuan Li, Ji-Jun Chen*. Anti-HBV agents. Part 3: Preliminary structures-activity relationships of tetra-acylalisol A derivatives as potent hepatitis B virus inhibitors. Bioorg Med Chem Lett, 2009, 19: 6659-6665

14. Quan Zhang, Zhi-Yong Jiang, Jie Luo, Ji-Feng Liu, Yun-Bao Ma, Rui-Hua Guo, Xue-Mei Zhang, Jun Zhou, Ji-Jun Chen*. Anti-HBV agents. Part 2: synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives. Bioorg Med Chem Lett, 2009, 19(8):2148-2153

15. Quan Zhang, Zhi-Yong Jiang, Jie Luo, Yun-Bao Ma, Xue-Mei Zhang, Feng-Xue Zhang, Jun Zhou, Ji-Jun Chen*. Anti-HBV agents. 1. Synthesis of alisol derivatives: a new class of hepatitis B virus inhibitors, Bioorg Med Chem Lett, 2008,18: 4647-4550

16. Meng-Hong Yan; Pi Cheng; Zhi-Yong Jiang; Yun-Bao Ma; Xue-Mei Zhang; Feng-Xue Zhang; Liu-Meng Yang; Yong-Tang Zheng; Ji-Jun Chen*. Periglaucines A–D, anti-HBV and HIV-1 Constituents from Pericampylus glaucus, J Nat Prod, 2008 71， 760-763

17. Pi Cheng, Quan Zhang, Yun-Bao Ma, Zhi-Yong Jiang, Xue-Mei Zhang, Feng-Xue Zhang, Ji-Jun Chen*, Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-ones and 5-aryl-7-chloro-1,4- benzodiazepines derivatives. Bioorg Med Chem Lett, 2008， 18：3787-3789

18. Pi Cheng, Ning Huang, Zhi-Yong Jiang, Quan Zhang, Yong-Tang Zheng, Xue-Mei Zhang, Yun-Bao Ma, Ji-Jun Chen*.1-Aryl-tetrahydroisoquinoline analogues as active anti-HIV agents in vitro. Bioorg Med Chem Lett, 2008, 18: 2475-2479

19. Qiong Gu, Xue-Mei Zhang, Jun Zhou, Sheng- Xiang Qiu, Ji-Jun Chen*.One new dihydrobenzofuran lignan from Vitex trifolia. J Asian Nat Prod Res, 2008, 10(6); 499-502

20. Xiu-Ming Cui, Zhi-Yong Jiang, Jiang Zeng, Jia Ming Zhou, JJi-Jun Chen*, Xue-Mei Zhang, Luo-Shang Xu, Qiang Wang. Two new damarane triterpene glycosides from the Rhizomes of Panax notoginseng. J Asian Nat Prod Res, 2008, 10 (9): 845-849

21. Pi Cheng, Yun-Bao Ma, Shu-ying Yao, Quang Zhang, En-jun Wang, Meng-Hong Yan, Xue-Mei Zhang, Feng-Xue, Zhang, Ji-Jun Chen*. Two New Alkaloids and Active Anti-Hepatitis B Virus Constituents from Hypserpa nitida. Bioorg Med Chem Lett, 2007, 17 :5315- 5320

22. Pi Cheng, Zhi-Yong Jiang, Rui-Rui Wang, Yong-Tang Zheng, Xue-Mei Zhang ,Ji-Jun Chen*, Synthesis and biological evaluations of -aryl-1,2-didehydroethylamines as new HIV-1 RT inhibitors in vitro.b-N-acetyl- Bioorg Med Chem Lett, 2007，17（16）：4476-4480

23. Ji-Feng Liu, Zhi-Yong Jiang, Rui-Rui Wang, Yong-Tang Zheng, Ji-Jun Chen*, Xue-Mei Zhang, Yun-Bao Ma. A novel alkaloid from leaves of Isatis indigotica Fort. Org Lett， 2007， 9（21）：4127-4129

24. Ying-Rui Wu, Yun-Bao Ma, You-Xing Zhao, Shu-Ying Yao, Jun Zhou, Ying Zhou, Ji-Jun Chen* Two new quaternary alkaloids and anti-Hepatitis B virus active constituents from Corydalis saxicol. Planta Med, 2007， 73 （8）：787-791

25. Wen-Yong Song, Yun-Bao Ma, Xue Bai, Xue-Mei Zhang, Qiong Gu, Yong-Tang Zheng, Zhou, Jun,Ji-Jun Chen* Two new compounds and anti-HIV active constituents from Illicium verum. Planta Med, 2007, 73:372- 375

26. Qiong Gu, Rui-Rui Wang, Xue-Mei Zhang, Yun-Hua Wang, Yong-Tang Zheng, Jun Zhou, Ji-Jun Chen*. A New Benzoguanolide and anti-HIV Active Constituents from the Stems of Rhus chinensis. Planta Med, 2007, 73: 279-282

27. Zhi-Yong Jiang, Xue-Mei Zhang, Jun Zhou, Feng-Xue Zhang, Ji-Jun Chen*，Yang LÜ, Li Wu, and Qi-Tai Zheng. Two new sesquiterpenes from Alisma orientalis. Chem. Pharm. Bull, 2007, 55: 905-907

28. Zhi-Yong Jiang, Xue-Mei Zhang, Feng-Xue Zhang, Ni Liu, Fang Zhao, Jun Zhou, Ji-Jun Chen*. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis , Panta Med, 2006, 72:951-954

29. Ning Li, Ji-Jun Chen, Jun Zhou. Two New Phenolic Glycosides from Rhizomes of Curculigo crassifolia. Z. Naturforrsch, 2006, 61b: 611-614

30. Rui-Rui Wang, Qiong Gu, Liu-Meng Yang, Ji-Jun Chen, Shun-Ying Li, Yong-Tang Zheng,. Anti-HIV activities of extracts from the medicinal plant Rhus chinensis, J Ethnopharmcology, 2006, 105 269- 273

31. Zhi-Yong Jiang, Xue-Mei Zhang, Jun Zhou，Sheng-xiang Qiu, Ji-Jun Chen*, Two new triterpenoid glycosides from Cyclocarya paliurus, J Asia Nat Prod Res,2006, 8:93-98

32. Ning Li, Kai-Jin Wang, Ji-Jun Chen, Jun Zhou. Two novel glucosyl-fused compounds from Curculigo crassifolia (Hypoxidaceae). Tetrahedron Lett, 2005, 46 (38): 6445-6447

33. Zhi-Yong Jiang, Xue-Mei Zhang, Jun Zhou, Ji-Jun Chen*. New triterpenoid glycoside from Centella asiatica, Helv Chim Acta, 2005, 88, 297-303

34. Ning LI, Ji-Jun Chen, You-XIing Zhao, Zhou Jun, Three new norlignans from Curculigo capitulate, J Asia Nat Prod Res, 2005, 7(3).189-195

35. Ning Li, Ji-Jun Chen, Jun Zhou. CapitulatinB, a new eudesmane derivative from Curculigo capitulate, and revised assignment of ¹³C NMR data of 6a, 15a- epoxy - 1b, 14b- dihydroxyeudesmane, J Asia Nat Prod Res, 2005, 7(3). 279 – 282