中国科学院昆明植物研究所
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研究生教育
药理学专业
 

姓  名:
熊文勇
学  科:
药理学
人才类别:
百人计划/云南省高端/研究员
电话/传真:
0871-65216939/65216750  
电子邮件:
xiong.wenyong@mail.kib.ac.cn
通讯地址:
云南省昆明市蓝黑路132号 650201
更多信息:
  
简历:

1995年9月-1999年7月,陕西师范大学,学士

1999年9月-2004年7月,中国科学院昆明动物研究所,博士

2004年9 月-2007年7月,美国南加州大学医学院 (University of Southern California) ,博士后

2007年7月-2010年 12 月,美国康乃尔大学医学院(Cornell University),博士后

2010年12月-至今,中国科学院昆明植物研究所,植物化学与西部植物资源持续利用国家重点实验室,研究员

研究领域:

1. 治疗2型糖尿病和肥胖的药物活性筛选及作用机制研究

2. 治疗2型糖尿病天然药物研发 

3. 脂肪细胞生成的调控 

4. 胰岛素受体信号通路调控的GLUT4膜转运 

社会任职:
获奖及荣誉:

1999年 陕西师范大学优秀毕业生 

2012年 中国科学院百人计划 

2013年 云南省高端科技人才 

代表论著:

1. Lan Gao, Junling Chen, Jing Gao, Hongda Wang*, Wenyong Xiong*. Super-resolution microscopy reveals the reorganization of GLUT4 on plasma membrane regulated by insulin resistance. Journal of Cell Science. 130: 396-405. (2017)  

2. Yuan Gao#, Yan-Fen Niu#, Fei Wang, Ping Hai, Fang Wang, Yin Dong, Wen-Yong Xiong*, Ji-Kai Liu*. Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa. Natural Products and Bioprospecting. 6(5):247-255. (2016)  

3. Qinghua Kong#, Lan Gao#, Yanfen Niu, Pianchou Gongpan, Yuhui Xu, Yan Li*, Wenyong Xiong*. RACK1 is required for adipogenesis. American Journal of Physiology-Cell Physiology. 311(5): C831-C836. (2016)  

4. Junling Chen, Tianzhou, Liu, Jing Gao, Lan Gao, Lulu Zhou, Mingjun Cai, Yan Shi, Wenyong Xiong, Junguang Jiang, Ti Tong*, Hongda Wang*. Variation in carbohydrates between Cancer and Normal Cell Membranes Revealed by Super-Resolution Fluorescence Imaging. Advanced Science. 3(12):1600270(2016) 

5. Pianchou Gongpan, Yanting Lu, Fang Wang, Yuhui Xu & Wenyong Xiong*. AS160 controls eukaryotic cell cycle and proliferation by regulating the CDK inhibitor p21. Cell Cycle. 15(13):1733-41. (2016)  

6. Kun Wei, Gang-Qiang Wang, Xue Bai, Yan-Fen, Niu, He-Ping Chen, Chun-Nan Wen, Zheng-Hui Li, Ze-Jun Dong, Zhi-Li Zuo*, Wen-Yong Xiong* and Ji-Kai Liu*. Structure-Based Optimization and Biological Evaluation of Pancreatic Lipase Inhibitors as Novel Potential Antiobesity Agents. Natural Products and Bioprospecting. 5 (3): 129-157. (2015) 

7. Hai-Jun Hu, Wei-Feng Tian, Yan-Ting Lu, Hai-Yang Liu, Jing Hu, Pian-Chou Gongpan, Fang Wang, Yu-Mei Zhang*, Wen-Yong Xiong*, Qing-Hua Kong*. The Development and Application of the Glucose Uptake Stimulating Cell Model. Plant diversity. 37(6):821-827. (2015) 

8. Li-Wen Tian, Mu-Ke Tao, Min Xu, Jing Hu, Hong-Tao Zhu, Wen-Yong Xiong, Dong Wang, Chong-Ren Yang, Ying-Jun Zhang*. Carboxymethyl- and Carboxyl-Catechins from Ripe Pu-er Tea. Journal of Agricultural and Food Chemistry, 62(50), 12229-12234. (2014) 

9. L. Amanda Sadacca, Joanne Bruno, Jennifer Wen, Wenyong Xiong, and Timothy E. McGraw*. Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs. Molecular Biology of the Cell. 24(16): 2544-2557. (2013) 

10. Cheng-Qin Liang, Jing Hu, Yi-Ming Shi, Shan-Zhai Shang, Xue Du, Rui Zhan, Wen-Yong Xiong,  Hong-Bin Zhang, Wei-Lie Xiao*, Han-Dong Sun*. Schisphenlignans A–E: Five New Dibenzocyclooctadiene Lignans from Schisandra sphenanthera. Chemical and Pharmaceutical Bulletin. 61(1):96-100. (2013) 

11. Wenyong Xiong, Ingrid Jordens, Eva Gonzalez and Timothy McGraw*. GLUT4 is sorted into vesicles whose accumulation beneath and insertion to the plasma membrane is differentially regulated by insulin and selectively by insulin resistance. Molecular Biology of the Cell. 21(8):1375-1386. (2010) 

12. Ingrid Jordens, Dorothee Molle#, Wenyong Xiong# (#equal contribution) and Timothy McGraw*. IRAP is a key regulator of GLUT4 trafficking by controlling sorting from endosomes to specialized insulin-regulated vesicles. Molecular Biology of the Cell. 21(12):2034-2044. (2010) 

13. Darren J Michael#, Wenyong Xiong# (#equal contribution), Xuehui Geng, Peter Drain and Robert H Chow*. Human Insulin Vesicle Dynamics During Pulsatile Secretion. Diabetes. 56(5):1277-1288. (2007) 

14. Peter Pyrko, Adel Kardosh, Weijun Wang, Wenyong Xiong, Axel H Schönthal, and Thomas C Chen*. HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. Cancer Research. 67(22):10920-10928. (2007) 

15. Darren J Michael, Haijiang Cai, Wenyong Xiong, Justin Ouyang and Robert H Chow*. Mechanisms of peptide hormone secretion. TRENDS in Endocrinology and Metabolism. 17(10):408-415. (2006) 

16.  Wenyong Xiong, Huiming Wei, Xiaojun Xiang, Zhifang Dong, Jun Cao, Yongfu Wang, Tianle Xu and Lin Xu*. The Effect of Acute Stress on LTP and LTD Induction in the Hippocampal CA1 Region of Anesthetized Rats at Three Different Ages. Brain Research. 1005(1-2): 187-192. (2004) 

17. Wenyong Xiong, Yuexiong Yang, Jun Cao, Huiming Wei, Chongli Liang, Shangchuan Yang and Lin Xu*. The stress experience dependent long-term depression disassociated with stress effect on spatial memory task. Neuroscience Research. 46(4): 415-421. (2003) 

承担科研项目情况:

1. 云南省科技厅-高端科技人才项目 

2. 中国科学院-百人计划项目

3. 国家自然科学基金委-面上项目

中国科学院昆明植物研究所

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