中国科学院昆明植物研究所
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研究生教育
药物化学专业
 

姓  名:
程永现
学  科:
药物化学
人才类别:
研究员
电话/传真:
0871-65223048  
电子邮件:
yxcheng@mail.kib.ac.cn
通讯地址:
云南省昆明市蓝黑路132号 650201
更多信息:
  
简历:
1990.9-1994.7:河南中医学院中药系,获医学学士学位;
1994.9-1997.7:成都中医药大学药学院,获医学硕士学位;
1997.9-2000.8:中国科学院昆明植物研究所植物化学研究室,获理学博士学位;
2000.9-2002.9:北京大学医学部血管医学研究所博士后;
2003.8-2005.2:德国耶拿大学药物生物学研究所从事德国洪堡基金博士后研究。
2002.9-2003.7: 于国家食品药品监督管理局药品审评中心(CDE)从事中药与天然药物的新药审评工作;
2005.2-2008.7: 中国科学院昆明植物研究所中药和复方化学急需人才引进,副研究员兼课题组长,硕士生导师;
2008.8-迄今:中国科学院昆明植物研究所研究员,博士生导师。 

  程永现研究员自2005年起一直致力于中药与天然药物的化学成分与生物学功能研究,内容涉及中药及天然药物化学成分的分离鉴定、定向活性测试、结构修饰及新药转化。负责了20余项科研项目,包括“十一五”(子课题)、“十二五”国家新药创制重大科技专项各1项,NSFC-云南联合基金重点项目1项,国家自然科学基金面上或青年项目3项,中国科学院知识创新工程重要方向性项目2项、重点部署项目子课题1项,云南省地方科技攻关项目1项等。曾经对九香虫、琵琶甲虫、黑蚂蚁、蟋蟀、灵芝、干漆等约40种具有重要药用背景的天然药物进行了较为深入和系统的化学成分研究,积累形成了一个存有1500余个化合物,320余个新化合物和4个新骨架在内的、有深入挖掘价值的天然化合物库,其具有化合物数量大,新化合物比例高,结构类型丰富,来源涵盖虫类中药、贵细中药及植物分泌的树脂性中药等特点。在中药和天然药物功效启发下,对化合物进行了多方面的定向生物活性筛选,高效地发现154个活性成分,对其中4个化合物围绕抗肺癌、抗纤维化、抗慢性肾病和抗焦虑进行了较为系统的作用机制和体内有效性评价,目前1个抗焦虑化合物已进入新药研发的中试阶段。迄今在国内外核心期刊发表学术论文118篇,其中SCI收录73篇(第一或通讯作者:68篇),ACS刊物20篇;申请专利36件,授权18件,3件已转让,1件即将转让。近5年来,针对我国慢性肾病流行的严峻形式,申请人与南方医院器官衰竭防治重点实验室候凡凡院士合作,将研究聚焦于抗慢性肾病(主要涉及糖尿病肾病和肾脏纤维化)中药及天然药物发现及其作用机制研究方面,研究对象聚焦与自然界昆虫中的小分子化合物。目前还任Organic Letters等多个国内、外杂志的审稿人,药用植物等多个专业委员会的委员,也曾应邀在化学生物学、药学等多次国内、国际会议上作报告。2009年结合专业撰写的提案中指出协同创新机制在云南医药发展中的关键作用,当年被评为云南省政协优秀提案;2012年被九三学社中央评为全国优秀社员;2012年作为九三学社第十次全国代表大会代表在京参加会议,并作为70后代表接受媒体采访;其先进事迹也曾被云南政协报、春城晚报、九三学社中央委员会网站等多次报道,在社会上产生了较好的影响。 

研究领域:
中药化学与生物学,包括:昆虫小分子活性物质;
名贵中药药效物质基础;基于天然分子杂化的结构修饰;抗慢性肾病与焦虑症药物研发;基于中医养生思想的健康产品研发。
社会任职:
获奖及荣誉:
代表论著:
    迄今已在国内外核心期刊发表学术论文40余篇,免疫抑制活性环肽申请并公开发明专利一项,参与的环肽研究获得2006年云南省自然科学一等奖(署名第七);2007年入选云南省第十批中青年学术技术带头人与后备人才;现任郑州大学药学院兼职教授,大理学院药学院客座教授,Molecules杂志审稿人。2005年以来,主要以化学和生物学手段开展中药和复方相关研究工作。

代表论著(2000年以来): 

1. Yong-Ming Yan, Jun Ai, Yan-Ni Shi, Zhi-Li Zuo, Bo Hou, Jie Luo, Yong-Xian Cheng*. (±)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3, Organic Letters, 2014, 16, 532535. 肾保护 

2. Jiang-Bo He, Jie Luo, Li Zhang, Yong-Min Yan, Yong-Xian Cheng*. Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors, Organic Letters, 2013, 15, 3602–3606. 肾保护 

3. Yong-Ming Yan, Jun Ai, Li-Li Zhou, Arthur C.K. Chung, Rong Li, Jing Nie, Ping Fang, Xin-Long Wang, Jie Luo, Qun Hu, Fan-FanHou, Yong-Xian Cheng*. Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of pSmad3 from Ganoderma lucidum, Organic Letters, 2013, 15, 5488–5491. 肾保护 

4. Qi Luo, Shu-Mei Wang, Qing Lu, Jie Luo, Yong-Xian Cheng*. Identification of Compounds from the Water Soluble Extract of Cinnamomum cassia Barks and Their Inhibitory Effects against High-Glucose-Induced Mesangial Cell, Molecules, 2013, 18, 10930–10943. 肾保护 

5. Mei Yang, Jiang-Bo He, Yong-Xian Cheng*, Sheng Jiang. Synthesis of 3-[(Z)-Pentadec-8-enyl]catechol and Its Anti-angiogenesis Activity, Chinese Journal of Organic Chemistry, 2013, 33, 1319–1325. 

6. Zhi-Fang Zhao, Li-Li Zhou, Xia Chen, Yong-Xian Cheng, Fan-Fan Hou, Jing Nie. Acortatarin A inhibits high glucose-induced extracellular matrix production in mesangial cells, Chinese Medical Journal, 2013, 126, 1230–1235. 肾保护 

7. Yang Yang, Yong-Ming Yan, Wei Wei, Jie Luo, Lan-Sheng Zhang, Xiao-Jiang Zhou, Peng-Cheng Wang, Yong-Xun Yang, Yong-Xian Cheng*. Anthraquinone derivatives from Rumex plants and endophytic Aspergillus fumigatus and their effects on diabetic nephropathy, Bioorganic & Medicinal Chemistry Letters, 2013, 23, 3905–3909. 肾保护 

8. Ying Liu, Ying Dong, Bo Zhang, Yong-Xian Cheng*. Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells, Oncology Letters, 2013, 6, 556-558. 

9.  Wen-Gui Li, Fei-Yan Dai, Yong-Xian Cheng*, Ge-Fen Yin, Jun-Long Bi, Dian-Peng Li. Identification of Porcine Reproductive and Respiratory Syndrome Virus Inhibitors through an Oriented Screening on Natural ProductsChemical Research in Chinese Universities, 2013, 29, 290-293. 

10. Yong-Ming Yan, Min Hu, Mei Yang, Xiao-Ping Dong and Yong-Xian Cheng*. Terpenoids from Incarvillea arguta, Journal of Asian Natural Products Research, 2013, 15, 9-14. 

11. Lin-Hong Zeng, Min Hu, Yong-Ming Yan, Qing Lu and Yong-Xian Cheng*. Compounds from the roots of Jasminum sambac, Journal of Asian Natural Products Research, 2012, 14, 1180-1185. 

12. Y-J Li, X Zhao, LM Vecchiarelli-Federico, Y Li, A Datti, Y Cheng and Y Ben-David. Drug-mediated inhibition of Fli-1 for the treatment of leukemia, Blood Cancer Journal, 2012, 2, e54 doi:10.1038/bcj.2011.52. 

13. Xiao-Jiang Zhou, Xue-Song Li, Ying Shen, Gang Pei, Jun-Feng Wang, Yong-Xian Cheng*. Steroids and Triterpenoids from Cucumis sativus Roots, Chemistry of Natural Compounds, 2012, 48, 419­422. 

14. Yong-Ming Yan, Huan-Qin Dai, Yuhong Du, Bernd Schneider, Hui Guo, Dian-Peng Li, Li-Xin Zhang, Haian Fu, Yong-Xian Cheng*. Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis, Bioorganic & Medicinal Chemistry Lettes, 2012, 22, 4179-4181. 

15. Yong-Ming Yan, Gui-Sheng Wu, Xiao-Ping Dong, Lan Shen, Yan Li, Jia Su, Huai-Rong Luo, Hua-Jie Zhu, and Yong-Xian Cheng*. Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation, Journal of Natural Products, 2012, 75, 1025-1029. 

16. Xi Li, Wei Cao, Ying Shen, Dian-Peng Li, Ning Li, Xiao-Ping Dong, Kai-Jin Wang, Yong-Xian Cheng*. Antioxidant compounds from Rosa laevigata fruits, Food Chemistry, 2012, 130, 575-580. 肾保护 

17. Chang-Wei Song, Shu-Mei Wang, Li-Li Zhou, Fan-Fan Hou, Kai-Jin Wang, Quan-Bin Han, Ning Li, Yong-Xian Cheng*. Isolation and identification of compounds responsible for antioxidant capacity of Euryale ferox Seeds, Journal of Agricultural and Food Chemistry, 2011, 59, 1199-1204. 肾保护 

18. Jun Zhao, Li-Li Zhou, Xi Li, Hong-Bin Xiao, Fan-Fan Hou,* and Yong-Xian Cheng*. Bioactive compounds from the aerial parts of Brachystemma calycinum and structural revision of an octacyclopeptide, Journal of Natural Products, 2011, 74, 13921400. 肾保护 

19. Yong-Xian Cheng*, Li-Li Zhou, Yong-Ming Yan, Ke-Xin Chen, Fan-Fan Hou. Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum, Bioorganic & Medicinal Chemistry Letters, 2011, 21, 74347439. 肾保护 

20. Xiao-Jiang Zhou, Xiao-Liang Chen, Xue-Song Li, Jia Su, Jiang-Bo He, Yue-Hu Wang, Yan Li, Yong-Xian Cheng*. Two dimeric lignans with an unusual alpha,beta-unsaturated ketone motif from Zanthoxylum podocarpum and their inhibitory effects on nitric oxide production, Bioorganic & Medicinal Chemistry Letters, 2011, 21, 373-376. 

21. Jun-Feng Wang, Ge-Fen Yin, Xiao-Jiang Zhou, Jia Su, Yan Li, Hui-Min Zhong, Gang Duan,* and Yong-Xian Cheng*. Flavonolignans from Hydnocarpus anthelminthica seeds inhibit nitric oxide production in LPS stimulated RAW 264.7 macrophage cell line, Journal of Asian Natural Products Research, 2011, 13, 80-83. 

22. Xiao-Jiang Zhou, Min Xu, Xue-Song Li, Yue-Hu Wang, Ye Gao, Rui Cai, Yong-Xian Cheng*. Triterpenoids and sterones from the stem bark of Ailanthus altissima, Bulletin of Korean Chemical Society, 2011, 32, 1-4. 

23. Ying Liu, Xiao-Qin Chen, Heng-Xing Liang, Feng-Xiang Zhang, Fan-Yi Meng, Yong-Xian Cheng*, and Guang-Biao Zhou*.  Small compound 6-O-angeloylplenolin induces mitotic arrest and exhibits therapeutic potential in multiple myeloma, PLoS ONE 6(7): e21930. 

24. Ren-Qiang Mei, Lin-Hong Zeng, Xiang-Tao Wang, Rui Chen, Huai-Rong Luo and Yong-Xian Cheng*. N-containing compounds from Broussonetia papyrifera seeds and their cAMP regulatory activity in N1E-115 cells, Chemistry of Natural Compounds, 2011, 47, 783785. 

25. Xiao-Jiang Zhou, Zhou Xie, Yong-Ming Yan, Xue-Song Li, Bing Wang, Yong-Xian Cheng*. A new lignan from the leaves of Loropetalum chinensis, Chemistry of Natural Compounds, 2011, 47, 690692. 

26. Jiangbo He, Yongming Yan, Guifen Luo, Xuesong Li, Jia Su, Yan Li, Guangming Liu, and Yongxian Cheng*. Sesquiterpenoids and Diarylheptanoids from an animal product nidus vespae and their inhibitory effects on nitric oxide production, Chemisty & Biodiversity, 2011, 8, 22702276.  

27. Xue-Song Li, Xiao-Jiang Zhou, Xing-Jie Zhang, Xue-Jing Li, Mei Yang, Yong-Ming Yan, Yong-Tang Zheng, Yan Li, Liu-Meng Yang, and Yong-Xian Cheng*. Sesquiterpenoidal and norsesquiterpenoidal derivatives from Sanicula lamelligera and their biological evaluation, Journal of Natural Products, 2011, 74, 15211525. 

28. Jun Zhao, Lin-Hong Zeng, Xi Li, Xiao-Ping Dong, Yong-Ming Yan, Yong-Xian Cheng*. Brachystemols A–C, three new furan derivatives from Brachystemma calycinum, Journal of Asian Natural Products Research, 2011, 13, 915919. 

29. Xiao-Gang Tong, Li-Li Zhou, Yue-Hu Wang, Chengfeng Xia, Ye Wang, Min Liang, Fan-Fan Hou,* and Yong-Xian Cheng*. Acortatarins A and B, Two Novel Antioxidative Spiroalkaloids with a Naturally Unusual Morpholine Motif from Acorus tatarinowii, Organic Letters, 2010, 12, 1844-1847. 肾保护 

30. Xiao-Gang Tong, Gui-Sheng Wu, Cheng-Gang Huang, Qing Lu, Yue-Hu Wang, Chun-Lin Long, Huai-Rong Luo, Hua-Jie Zhu,*, and Yong-Xian Cheng*. Compounds from Acorus tatarinowii: Determination of the absolute configurations by quantum computations and cAMP regulation activity, Journal of Natural Products, 2010, 73, 1160-1163. 

31. Jun Zhao, Hua-Jie Zhu, Xiao-Jiang Zhou, Tong-Hua Yang, Yuan-Yuan Wang, Jia Su, Yan Li*, and Yong-Xian Cheng*. Diterpenoids from Trogopterus xanthipes, Journal of Natural Products, 2010, 73, 865-869. 

32. Xiao-Gang Tong, Jin-Lei Liu and Yong-Xian Cheng*. A new pregnane steroid from Poria cum Radix Pini, Journal of Asian Natural Products Research, 2010, 12, 419-423. 

33. Xiao-Jiang Zhou, Ren-Qiang Mei, Li Zhang, Qing Lu, Jun Zhao, Abiodun Humphrey Adebayo, Yong-Xian Cheng *. Antioxidant phenolics from Broussonetia papyrifera fruits, Journal of Asian Natural Products Research, 2010, 12, 399-406. 

34. Heng-Xing Liang, Huan-Qin Dai, Hai-An Fu, Xiao-Ping Dong, Abiodun Humphrey Adebayo, Li-Xin Zhang,* Yong-Xian Cheng*. Bioactive compounds from the roots of Rumex nepalensis, Phytochemistry Letters, 2010, 3, 181-184. 

35. Jiangbo He, Huajie Zhu, Guifen Luo, Guangming Liu, Hao Chen, Yan Li, Shaopeng Chen, Xin Lu, Guochun Zhou, Yongxian Cheng*. New compounds from Euphorbia helioscopia and absolute configuration determination by computational methods, Bulletin of Korean Chemical Society, 2010, 31, 2211-2214. 

36. Junfeng Wang, Huanqin Dai, Yuling Wei, Huajie Zhu, Yongming Yan, Yuehu Wang, Chunlin Long, Huimin Zhong, Lixin Zhang*, and Yongxian Cheng*. Anti-tuberculosis agents and an inhibitor of para-Aminobenzoic Acid biosynthetic pathway from Hydnocarpus anthelminthica seeds, Chemistry & Biodiversity, 2010, 7, 2046-2053. 

37. Xiao-Gang Tong, Bin Qiu, Gui-Fen Luo, Xiao-Fang Zhang, Yong-Xian Cheng*. Alkaloids and sesquiterpenoids from Acorus tatarinowii, Journal of Asian Natural Products Research, 2010, 12, 438-442. 

38. Li Zhang, Yong-Xian Cheng, Ai-Lin Liu, Hai-Di Wang, Ya-Ling Wang, Guan-Hua Du*. Anti-oxidant, anti-inflammatory, anti-influenza properties of compounds from Chaenomeles speciosa, Molecules, 2010, 15, 8507-8517. 

承担科研项目情况:
2005年以来承担各类项目共计27项,总经费1200余万元,代表性课题如下: 

1. 中国科学院重点部署项目子课题,尼泊尔酸模与鹅不食草的药效物质与质量标准制定(KSZD-E-W-Z-004, 2013-201550万) 

2. 十二五国家重大科技专项, 新型NMDA受体拮抗剂瑞莱克斯抗焦虑症候选药物研究(2012ZX09103201-0522011-2015143万) 

3. NSFC-云南联合基金重点项目,抗脏器纤维化先导化合物GQ-5的作用机制、构效优化与成药性研究(U12022222013-2016214万) 

4. 国家自然科学基金,云南彝族特色药用昆虫日本琵琶甲功效关联成分及作用机制研究211722232012-201560万) 

5. 十一五国家重大科技专项子课题,脑血管-神经系统疾患创新药物产学研示范基地建设(2008ZX09401-0042008-2010300万) 

6. 地方科技攻关计划,重要动物药特色分子及其强生理活性成分(2009AC0112009-201166万) 

7. 国家自然科学基金,酸模属植物NMDA受体拮抗剂构效关系与作用机制研究(209721652010-201230万) 

8. 国家自然科学基金,抗风湿药短瓣花中含氮化合物及其免疫抑制活性与作用机制307000592008-201016万) 

9. 中国科学院西部之光联合学者项目,若干中药功效成分及其应用前景评价(2007-201030万)
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