中国科学院昆明植物研究所
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研究生教育
药物化学专业
 

姓  名:
赵勤实
学  科:
药物化学
人才类别:
研究员
电话/传真:
0871-65223058  
电子邮件:
qinshizhao@mail.kib.ac.cn
通讯地址:
云南省昆明市蓝黑路132号 650201
更多信息:
  
简历:
赵勤实,博士,二级研究员,博士生导师,中国科学院特聘研究员,享受云南省政府特殊津贴。1993-1995年,中国科学院昆明植物研究所植物化学专业,理学博士;1995-1998年,军事医学科学院毒物研究所博士后;1998年至今在中国科学院昆明植物研究所工作,期间先后在日本静冈县立大学和美国伊利诺伊大学芝加哥药学院做访问学者。现任植物化学与西部植物资源持续利用国家重点实验室副主任、云南省天然药物化学重点室副主任,研究所学术委员会委员。国家药审中心新药审评专家,云南省科学技术一等奖获得者(2003),国际SCI期刊《Chemistry & Biodiversity》编委会主席,蕨类植物协会副理事长。曾兼任研究所公共技术服务中心主任,广西功能物质研究与开发重点实验室学术委员会主任。长期从事创新药与中药现代化研究,以通讯作者或共同通讯作者在J. Am. Chem. Soc., Cancer Res., J. Med. Chem.Eur. J. Med. Chem.OncotargetChem. Commun.Org. Lett.TetrahedronTetrahedron Lett.Bioorg. Med. Chem.等国际杂志上发表120多篇论文,授权专利10项。
研究领域:

创新药与中药现代化

社会任职:
获奖及荣誉:
香茶菜属植物二萜成分及生物活性的研究获2003年云南科学技术一等获。
代表论著:

1. Xu, J.; Shao, L.-D.; Li, D.; Deng, X.; Liu, Y.-C.; Zhao, Q.-S.*; Xia, C.-F.*, Construction of tetracyclic 3-spirooxindole through cross-dehydrogenation of pyridinium: applications in facile synthesis of (±)-corynoxine and (±)-corynoxine B. Journal of the American Chemical Society, 2014, 136, 17962-17965.

2. Yu, Z.-Y.; Xiao, H.; Wang, L.-M.; Shen, X.; Jing, Y.; Wang, L.; Sun, W.-F.; Zhang, Y.-F.; Cui, Y.; Shan, Y.-J.; Zhou, W.-B.; Xing, S.; Xiong, G.-L.; Liu, X.-L.; Dong, B.; Feng, J.-N.; Wang, L.-S.; Luo, Q.-L.; Zhao, Q.-S.*; Cong, Y.-W.*, Natural product vibsanin A induces differentiation of myeloid leukemia cells through PKC activation. Cancer Research, 2016, 76, 2698-2709.

3. Shao, L.-D.; Su, J.; Ye, B.-X.; Liu, J.-X.; Zuo, Z.-L.; Wang, Y.-Y.*; Xia, C.-F.*; Zhao, Q.-S.*, Design, synthesis, and biological activities of vibsanin B derivatives: a new class of HSP90 C-terminal inhibitors. Journal of Medicinal Chemistry, 2017, 60, 9053-9066.

4. Zhao, Y.; Su, J.; Goto, M.; Morris-Natschke, S. L.; Li, Y.; Zhao, Q.-S.*; Yao, Z.-J.*; Lee, K.-H.*, Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation. Journal of Medicinal Chemistry, 2013, 56, 4749-4757.

5. Ye, B.-X.; Deng, X.; Shao, L.-D.; Lu, Y.; Xiao, R.; Liu, Y.-J.; Jin, Y.; Xie, Y.-Y.; Zhao, Y.; Luo, L.-F.; Ma, S.; Gao, M.; Zhang, L.-R.; He, J.; Zhang, W.-N.; Chen, Y.; Xia, C.-F.; Deng, M.; Liu, T.-X.; Zhao, Q.-S.*; Chen, S.-J.*; Chen, Z.*, Vibsanin B preferentially targets HSP90β, inhibits interstitial leukocyte migration, and ameliorates experimental autoimmune encephalomyelitis. The Journal of  Immunology, 2015, 194, 4489-4497.

6. Zhang, Z.-J.; Nian, Y.; Zhu, Q.-F.; Li, X.-N.; Su, J.; Wu, X.-D.; Yang, J.*; Zhao, Q.-S.*, Lycoplanine A, a C16N Lycopodium alkaloid with a 6/9/5 tricyclic skeleton from Lycopodium complanatum. Organic Letters, 2017, 19, 4668-4671.

7. Dong, L.-B.; Wu, X.-D.; Shi, X.; Zhang, Z.-J.; Yang, J.; Zhao, Q.-S.*, Phleghenrines A-D and neophleghenrine A, bioactive and structurally rigid Lycopodium alkaloids from Phlegmariurus henryi. Organic Letters, 2016, 18, 4498-4501.

8. Ren, J.; Shi, X.; Li, X.-N.; Li, L.-W.; Su, J.; Shao, L.-D.*; Zhao, Q.-S.*, Synthesis of a small-molecule library with skeletal diversity from hemslecin A via the reaction-discovery strategy. Organic Letters, 2016, 18, 3948-3951.

9. Wu, X.-D.; Luo, D.; Tu, W.-C.; Deng, Z.-T.; Chen, X.-J.; Su, J.; Ji, X.*; Zhao, Q.-S.*, Hypophyllins A-D, labdane-type diterpenoids with Vasorelaxant activity from Hypoestes phyllostachya "Rosea". Organic Letters, 2016, 18, 6484-6487.

10. Gao, X.; Shao, L.-D.; Dong, L.-B.; Cheng, X.; Wu, X.-D.; Liu, F.; Jiang, W.-W.; Peng, L.-Y.; He, J.*; Zhao, Q.-S.*, Vibsatins A and B, two new tetranorvibsane-type diterpenoids from Viburnum tinus cv. variegatus. Organic Letters, 2014, 16, 980-983.

11. Dong, L.-B.; Wu, Y.-N.; Jiang, S.-Z.; Wu, X.-D.; He, J.; Yang, Y.-R.*; Zhao, Q.-S.*, Isolation and complete structural assignment of Lycopodium alkaloid cernupalhine A: theoretical prediction and total synthesis validation. Organic Letters, 2014, 16, 2700-2703.

12. Dong, L.-B.; Gao, X.; Liu, F.; He, J.; Wu, X.-D.; Li, Y.; Zhao, Q.-S.*, Isopalhinine A, a unique pentacyclic Lycopodium alkaloid from Palhinhaea cernua. Organic Letters, 2013, 15, 3570-3573.

13. Cheng, J.-T.; Liu, F.; Li, X.-N.; Wu, X.-D.; Dong, L.-B.; Peng, L.-Y.; Huang, S.-X.; He, J.*; Zhao, Q.-S.*, Lycospidine A, a new type of Lycopodium alkaloid from Lycopodium complanatum. Organic Letters, 2013, 15, 2438-2441.

14. He, J.; Chen, X.-Q.; Li, M.-M.; Zhao, Y.; Xu, G.; Cheng, X.; Peng, L.-Y.; Xie, M.-J.; Zheng, Y.-T.; Wang, Y.-P.; Zhao, Q.-S.*, Lycojapodine A, a novel alkaloid from Lycopodium japonicum. Organic Letters, 2009, 11, 1397-1400.

15. Xu, G.; Hou, A.-J.; Zheng, Y.-T.; Zhao, Y.; Li, X.-L.; Peng, L.-Y.; Zhao, Q.-S.*, Przewalskin B, a novel diterpenoid with an unprecedented skeleton from Salvia przewalskii Maxim. Organic Letters, 2007, 9 (2), 291-293.

16. Xu, G.; Hou, A.-J.; Wang, R.-R.; Liang, G.-Y.; Zheng, Y.-T.; Liu, Z.-Y.; Li, X.-L.; Zhao, Y.; Huang, S.-X.; Peng, L.-Y.; Zhao, Q.-S.*, Przewalskin A: A new C23 terpenoid with a 6/6/7 Ccarbon ring Sskeleton from Salvia przewalskii Maxim. Organic Letters, 2006, 8, 4453-4456.

17. Li, X.-L.; Cheng, X.; Yang, L.-M.; Wang, R.-R.; Zheng, Y.-T.; Xiao, W.-L.; Zhao, Y.; Xu, G.; Lu, Y.; Chang, Y.; Zheng, Q.-T.; Zhao, Q.-S.*; Sun, H.-D., Dichotomains A and B: two new highly oxygenated phenolic derivatives from Dicranopteris dichotoma. Organic Letters, 2006, 8, 1937-1940.

18. Dong, L.-B.; Yang, J.; He, J.; Luo, H.-R.; Wu, X.-D.; Deng, X.; Peng, L.-Y.; Cheng, X.; Zhao, Q.-S.*, Lycopalhine A, a novel sterically congested Lycopodium alkaloid with an unprecedented skeleton from Palhinhaea cernua. Chemical Communications, 2012, 48, 9038-9040.

19. Shi, X.; Deng, Z.-T.; Zhu, Y.; Bao, Y.; Shao, L.-D.*; Zhao, Q.-S.*, Total synthesis of (±)-cermizine B. Journal of Organic Chemistry, 2017, DOI: 10.1021/acs.joc.7b02073.

20. Shao, L.-D.; Bao, Y.; Shen, Y.; Su, J.; Leng, Y.*; Zhao, Q.-S.*, Synthesis of selective 11β-HSD1 inhibitors based on dammarane scaffold. European Journal of Medicinal Chemistry, 2017, 135, 324-338.

21. Deng, X.; Shen, Y.; Yang, J.; He, J.; Zhao, Y.; Peng, L.-Y.; Leng, Y.*; Zhao, Q.-S.*, Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: Potential impact in diabetes. European Journal of Medicinal Chemistry, 2013, 65, 403-414.

22. Deng, X.; Su, J.; Zhao, Y.; Peng, L.-Y.; Li, Y.; Yao, Z.-J.*; Zhao, Q.-S.*, Development of novel conformation-constrained cytotoxic derivatives of cheliensisin A by embedment of small heterocycles. European Journal of Medicinal Chemistry, 2011, 46, 4238-4244.

23. Zhao, Y.; Niu, X.-M.; Qian, L.-P.; Liu, Z.-Y.*; Zhao, Q.-S.*; Sun, H.-D., Synthesis and cytotoxicity of some new eriocalyxin B derivatives. European Journal of Medicinal Chemistry, 2007, 42, 494-502.

24. Chen, X.-Q.; Shao, L.-D.; Pal, M.; Shen, Y.; Cheng, X.; Xu, G.; Peng, L.-Y.; Wang, K.; Pan, Z.-H.; Li, M.-M.; Leng, Y.; He, J.*; Zhao, Q.-S.*, Hupehenols A-E, selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors from Viburnum hupehense. Journal of Natural Prodroducts, 2015, 78, 330-334.

25. Wu, X.-D.; He, J.; Li, X.-Y.; Dong, L.-B.; Gong, X.; Song, L.-D.; Li, Y.; Peng, L.-Y.; Zhao, Q.-S.*, Diterpenoids from the twigs and leaves of Fokienia hodginsii. Journal of Natural Prodroducts, 2013, 76, 1032-1038.

26. Dong, L.-B.; He, J.; Wang, Y.-Y.; Wu, X.-D.; Deng, X.; Pan, Z.-H.; Xu, G.; Peng, L.-Y.; Zhao, Y.; Li, Y.; Gong, X.; Zhao, Q.-S.*, Terpenoids and norlignans from Metasequoia glyptostroboides. Journal of Natural Prodroducts, 2011, 74, 234-239.

27. Wang, K.; Zhou, X.-Y.; Wang, Y.-Y.; Li, M.-M.; Li, Y.-S.; Peng, L.-Y.; Cheng, X.; Li, Y.; Wang, Y.-P.*; Zhao, Q.-S.*, Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla. Journal of Natural Prodroducts, 2011, 74, 12-15.

28. Pan, Z.-H.; Wang, Y.-Y.; Li, M.-M.; Xu, G.; Peng, L.-Y.; He, J.; Zhao, Y.; Li, Y.; Zhao, Q.-S.*, Terpenoids from Salvia trijuga. Journal of Natural Prodroducts, 2010, 73, 1146-1150.

29. Li, X.-L.; Yang, L.-M.; Zhao, Y.; Wang, R.-R.; Xu, G.; Zheng, Y.-T.; Tu, L.; Peng, L.-Y.; Cheng, X.; Zhao, Q.-S.*, Tetranorclerodanes and clerodane-type diterpene glycosides from Dicranopteris dichotoma. Journal of Natural Prodroducts, 2007, 70, 265-268.

30. Zhao, Y.; Wang, F.-S.; Peng, L.-Y.; Li, X.-L.; Xu, G.; Luo, X.-X.; Lu, Y.; Wu, L.; Zheng, Q.-T.; Zhao, Q.-S.*, Taxoids from Taxus chinensis. Journal of Natural Prodroducts, 2006, 69, 1813-1815.
承担科研项目情况:

作为课题负责人承担973课题1项、作为学术骨干参加973项目1项,主持国家基金委云南省联合基金重点项目2项,主持国家基金面上项目、化学生物学重大研究计划课题多项。

1 NSFC-云南省联合基金项目(U1502223)2016/01-2019/12

2、国家重点基础研究发展计划子课题(2011CB915503)2011/01-2015/12

3NSFC-云南省联合基金项目(U0932602)2010/01-2013/12

4、国家自然科学基金重大研究计划培育项目(90813004)2009/01-2011/12

5、国家自然科学基金面上项目(30171073)2002/01-2004/12
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