中国科学院昆明植物研究所
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研究生教育
药物化学专业
 

姓  名:
汪亮亮
学  科:
药物化学
人才类别:
副研究员
电话/传真:
0871-65227196  
电子邮件:
wangliangliang@mail.kib.ac.cn
通讯地址:
昆明市蓝黑路132号 650201
更多信息:
  
简历:

2003.09-2007.07 安徽大学,理学学士

2007.09-2009.09 中国科学院成都有机化学研究所,硕士

2009.09-2012.06 中国科学院成都有机化学研究所,理学博士

2012.11-2013.11 法国综合理工大学(ÉcolePolytechnique),博士后

2013.12-2016.12 德国汉诺威大学(Leibniz Universität Hannover),博士后

2017.03现在  中国科学院昆明植物研究所,副研究员,硕士生导师

研究领域:

主要从事具有复杂结构的天然产物的全合成研究,并以全合成为工具,对天然产物进行结构改造,合成具有潜在成药性的天然药物分子。目前已完成多个具有良好抗菌活性的Polyketide 分子Elansolid B1/B2, 20-deoxy Elasolid B1等的全合成。迄今已在Chemistry - A European Journal Chemical Communications Journal of Organic Chemistry 等国际核心期刊发表 SCI 文章20余篇,并以共同发明人身份发表国际专利2篇。

社会任职:
获奖及荣誉:

1、2011.12 获得中科院成都分院院长奖学金,一等;

2、2012.03 获得中国科学院朱李月华冠名奖;

3、2012.10 获得法国综合理工大学博士后奖学金

代表论著:

1.      Liang Liang WangDavid CanditoGerald DrägerJennifer HermannRolf MüllerAndreas Kirschning* Harnessing a p-quinone methide intermediate in the biomimetic total synthesis of the highly active antibiotic 20-deoxy-elansolid B1 Chem. Eur. J.2017235291

2.      Liang Liang WangAsha BalakrishnanDavid CanditoYu XieKatja Seidel Michael OttAndreas Kirschning* A bio-chemosynthetic approach to superparamagnetic iron oxide - ansamitocinconjugates for use in magnet drug targetingChem. Eur. J.2017232265

3.      Liang Liang Wang, A. Kirschning, *Total synthesis of elansolids B1 and B2, Beilstein J. Org. Chem, 2017, Beilstein J. Org. Chem. 2017, 13, 1280

4.      Katja Seidel, Asha Balakrishnan, Christoph Alexiou, Christina Janko, Ronja-Melinda Komoll, Liang-Liang Wang, Andreas Kirschning*, Michael Ott*, Synthesis of magnetic nanoparticle-ansamitocin conjugates – inductive heating leads to decreased cell proliferation in vitro and attenuation of tumour growth in vivo, Chem. Eur. J.2017DOI: 10.1002/chem.201701491

5.      Baumann Sascha, Herrmann Jennifer, Mohr Kathrin, Steinmetz Heinrich,Gerth Klaus, Raju Ritesh, Muller Rolf, Hartmann  Rolf, Hamed Mostafa, Elgaher Walid Am, Moreno Maria, Gelle Franziska, WangLiangLiang, Kirschning Andereas, Cystobactamides, 2016, US201414904654

6.      Baumann Sascha, Herrmann Jennifer, Mohr Kathrin, Steinmetz Heinrich, Gerth Klaus, Raju Ritesh, Muller Rolf, Hartmann  Rolf, Hamed Mostafa, Elgaher Walid Am, Moreno Maria, Gelle Franziska, Wang LiangLiang, Kirschning Andereas, Huttel Stephan, Novel Cystobactamides, 2016, WO2015EP02382

7.      Liang-Wen Qi, Liang-Liang Wang, Lin Peng, Li-Na Jia, Fang Tian, Xiao-Ying Xu,* Li-Xin Wang,* A novel asymmetric organocatalytic Michael–aldol–dehydration domino reaction for the construction of spirocyclicbenzofuranones, Tetrahedron, 2013, 69, 9303.

8. Liang-Liang Wang, Jian-Fei Bai, Lin Peng, Liang-Wen Qi, Li-Na Jia, Yun-Long Guo, Xi-Ya Luo, Xiao-Ying Xu* and Li-Xin Wang, *Organocatalyticstereocontrolled synthesis of 3,3′-pyrrolidinyl spirooxindoles by [3+2] annulation of isocyanoesters with methyleneindolinones, Chem. Commun., 2012, 48, 5175.

9.      Jian-Fei Bai, Liang-Liang Wang, Li Peng, Yun-Long, Li-Na Jia, Fang Tian, Guang- Yun He, Xiao-Ying Xu, * Li-Xin Wang, * Asymmetric Michael addition of α- substistutedisocynoacetates with maleimides catalyzed by chiral tertiary amine thiourea, J. Org. Chem. 2012, 77, 2947.

10. Liang-Liang Wang, Lin Peng, Jian-Fei Bai, Li-Na Jia, Xi-Ya Luo, Qing-Chun Huang, Xiao-Ying Xu* and Li-Xin Wang, * Highly organocatalyticstereoselectivedouble Michael reaction: efficient construction of optically enriched spirocyclicoxindoles. Chem. Commun.,2011, 47, 5593.

11. Liang-Liang Wang, Lin Peng, Jian-Fei Bai, Qing-Chun Huang, Xiao-Ying Xu, *Li-Xin Wang, *Highly organocatalyticasymmetric Michael-ketone aldol-dehydration domino reaction: straightforward approach to construct six-membered spirocyclicoxindoles, Chem. Commun.,2010, 46, 8064.

12. Liang-Liang Wang, Xiao-Ying Xu,Jun Huang, Lin Peng, Qing-ChunHuang, Li-Xin Wang, *Asymmetric Michael addition of aromatic ketones to nitroolefins catalyzed bysimple chiral bifunctional primary amine-thioureas. Lett.Org. Chem., 2010, 7, 367.

承担科研项目情况:
中国科学院昆明植物研究所人才引进启动基金 (Y7671211K1)50万,2017.03-2020.03
中国科学院昆明植物研究所

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